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Tclin
HCAR2
Hydroxycarboxylic acid receptor 2

Protein Summary
Description
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328880
  • ENSP00000375066
  • ENSG00000182782

Symbol
  • GPR109A
  • HCA2
  • HM74A
  • NIACR1
  • HCA2
  • HM74a
  • HM74b
  • PUMAG
  • NIACR1
  • Puma-g
  • GPR109A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.76
chemical
0.63
cell line
0.62
biological process
0.57
biological term
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.12   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.12   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 204
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2