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Tchem
STK35
Serine/threonine-protein kinase 35

Protein Summary
Description
The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381482
  • ENSP00000370891
  • ENSG00000125834

Symbol
  • CLIK1
  • PDIK1
  • STK35L1
  • CLIK1
  • STK35L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
transcription factor binding site profile
0.88
microRNA
0.83
PubMedID
0.64
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.7   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.7   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
bosutinib
chemical structure image
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (56)
1 – 10 of 56
CTDSPL2
Tbio
Family: Enzyme
Novelty: 0.23529412
p_int: 0.999999996
p_ni: 3e-9
p_wrong: 1e-9
Score: 0.298
Data Source: BioPlex,STRINGDB
HSP90AB3P
Tdark
p_int: 0.99999946
p_ni: 5.4e-7
Data Source: BioPlex
HSP90AA5P
Tdark
p_int: 0.99999883
p_ni: 0.00000117
Data Source: BioPlex
HSP90AB4P
Tdark
p_int: 0.999994841
p_ni: 0.000005157
p_wrong: 2e-9
Data Source: BioPlex
C1orf174
Tdark
Novelty: 5
p_int: 0.999992263
p_ni: 0.000007737
Score: 0.282
Data Source: BioPlex,STRINGDB
CDC37L1
Tbio
Novelty: 0.07264148
p_int: 0.99999015
p_ni: 3.31e-7
p_wrong: 0.000009519
Score: 0.285
Data Source: BioPlex,STRINGDB
HSP90AA4P
Tdark
p_int: 0.999989068
p_ni: 0.000010668
p_wrong: 2.64e-7
Data Source: BioPlex
UBP1
Tbio
Family: TF
Novelty: 0.01787931
p_int: 0.999593298
p_ni: 0.0004067
p_wrong: 2e-9
Score: 0.747
Data Source: BioPlex,STRINGDB
CDC37
Tbio
Novelty: 0.0735786
p_int: 0.997028957
p_ni: 0.002971043
Score: 0.18
Data Source: BioPlex,STRINGDB
HSP90AA1
Tchem
Novelty: 0.00020424
p_int: 0.991105975
p_ni: 0.008894025
Score: 0.165
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  6.70

PubMed score by year
PubTator Score  5.48

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Sequence
MGHQESPLARAPAGGAAYVKRLCKGLSWREHVESHGSLGAQASPASAAAAEGSATRRARAATSRAARSRR
1-70
QPGPGADHPQAGAPGGKRAARKWRCAGQVTIQGPAPPRPRAGRRDEAGGARAAPLLLPPPPAAMETGKDG
70-140
ARRGTQSPERKRRSPVPRAPSTKLRPAAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGR
140-210
GSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSH
210-280
GNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAF
280-350
LHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDF
350-420
YMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHI
420-490
PQKRRTSMSEGIKQLLKDMLAANPQDRPDAFELETRMDQVTCAA
490-534
MGHQESPLARAPAGGAAYVKRLCKGLSWREHVESHGSLGAQASPASAAAAEGSATRRARAATSRAARSRRQPGPGADHPQAGAPGGKRAARKWRCAGQVTIQGPAPPRPRAGRRDEAGGARAAPLLLPPPPAAMETGKDGARRGTQSPERKRRSPVPRAPSTKLRPAAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPDAFELETRMDQVTCAA