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Tbio
ACER1
Alkaline ceramidase 1

Protein Summary
Description
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity). Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301452
  • ENSP00000301452
  • ENSG00000167769

Symbol
  • ASAH3
  • ASAH3
  • ALKCDase1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
cell type or tissue
0.65
biological process
0.61
cellular component
0.51
metabolite
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.19   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.19   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (100)
1 – 10 of 100
ASAH2
Tbio
Family:  Enzyme
Novelty:  0.01413539
Score:  0.971
Data Source:  STRINGDB
CERK
Tchem
Family:  Kinase
Novelty:  0.0103948
Score:  0.963
Data Source:  STRINGDB
SPHK1
Tchem
Family:  Kinase
Novelty:  0.00147889
Score:  0.962
Data Source:  STRINGDB
SPHK2
Tchem
Family:  Kinase
Novelty:  0.00454527
Score:  0.962
Data Source:  STRINGDB
SGMS2
Tchem
Family:  Enzyme
Novelty:  0.01360669
Score:  0.959
Data Source:  STRINGDB
UGCG
Tclin
Family:  Enzyme
Novelty:  0.00481791
Score:  0.958
Data Source:  STRINGDB
ASAH1
Tchem
Family:  Enzyme
Novelty:  0.00374228
Score:  0.952
Data Source:  STRINGDB
SGMS1
Tchem
Family:  Enzyme
Novelty:  0.01717229
Score:  0.949
Data Source:  STRINGDB
DEGS2
Tbio
Family:  Enzyme
Novelty:  0.02360852
Score:  0.948
Data Source:  STRINGDB
GBA2
Tchem
Family:  Enzyme
Novelty:  0.01340895
Score:  0.947
Data Source:  STRINGDB
Pathways (9)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
58.4
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alkaline ceramidase 1
VGNC:2083
468681
Macaque
alkaline ceramidase 1
699093
Mouse
MGI:2181962
171168
Rat
RGD:1588582
301118
Dog
alkaline ceramidase 1
VGNC:37504
611739
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alkaline ceramidase 1
Macaque
alkaline ceramidase 1
Mouse
Rat
Dog
alkaline ceramidase 1
Publication Statistics
PubMed Score 16.19
PubMed score by year
PubTator Score 3.50
PubTator score by year