Tbio BRIX1 Ribosome biogenesis protein BRX1 homolog

Protein Summary

Description

Required for biogenesis of the 60S ribosomal subunit.

Uniprot Accession IDs

• Q8TDN6
• A8K0P5
• Q3ZTT4
• Q8N453
• Q96DH1

Gene Name

• BRIX1

Ensembl ID

• ENST00000336767
• ENSP00000338862
• ENSG00000113460

Symbol

• BRIX
• BXDC2
• BRIX
• BXDC2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.97
histone modification site profile	0.9
transcription factor binding site profile	0.76
transcription factor perturbation	0.74
kinase perturbation	0.66

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Ribosome Biogenesis Protein Brx1 Homolog

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Ribosome Biogenesis Protein Brx1 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.92   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 192   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.92   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0