You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CABLES1
CDK5 and ABL1 enzyme substrate 1

Protein Summary
Description
Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256925
  • ENSP00000256925
  • ENSG00000134508
  • ENST00000400473
  • ENSP00000383321
  • ENST00000420687
  • ENSP00000413851

Symbol
  • CABLES
  • CABL1
  • IK3-1
  • CABLES
  • HsT2563
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
transcription factor binding site profile
0.72
cell type or tissue
0.7
transcription factor
0.68
microRNA
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.13   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.13   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
3
3
97.3
body height
6
4
8
6.4
96
platelet count
6
1
4
2.7
90.3
heel bone mineral density
2
2
2
89.1
mean platelet volume
3
1
3
84.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
97.3
body height
8
6.4
96
platelet count
4
2.7
90.3
heel bone mineral density
2
89.1
mean platelet volume
3
84.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Cdk5 and Abl enzyme substrate 1
VGNC:5147
455335
Macaque
Cdk5 and Abl enzyme substrate 1
706007
Mouse
MGI:1927065
63955
Rat
RGD:1305516
307585
Dog
Cdk5 and Abl enzyme substrate 1
VGNC:38622
100682687
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Cdk5 and Abl enzyme substrate 1
Macaque
Cdk5 and Abl enzyme substrate 1
Mouse
Rat
Dog
Cdk5 and Abl enzyme substrate 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TDN4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A:Cdk2-associated events at S phase entry
Reactome
Cyclin E associated events during G1/S transition
Reactome
Factors involved in megakaryocyte development and platelet production
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin A:Cdk2-associated events at S phase entry
Cyclin E associated events during G1/S transition
Factors involved in megakaryocyte development and platelet production
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (69)
1 – 10 of 69
FIBP
Tbio
Novelty: 0.11312115
p_int: 0.999999302
p_ni: 2e-8
p_wrong: 6.78e-7
Score: 0.857
Data Source: BioPlex,STRINGDB
CDK5
Tchem
Family: Kinase
Novelty: 0.00071394
p_int: 0.999953923
p_ni: 0.000046071
p_wrong: 6e-9
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
DLK1
Tchem
Novelty: 0.00212394
p_int: 0.998943186
p_ni: 0.000064717
p_wrong: 0.000992098
Score: 0.543
Data Source: BioPlex,STRINGDB
GOPC
Tbio
Novelty: 0.01110168
p_int: 0.878157214
p_ni: 0.000643827
p_wrong: 0.121198959
Score: 0.193
Data Source: BioPlex,STRINGDB
TDRD7
Tbio
Family: Epigenetic
Novelty: 0.03580848
Score: 0.972
Data Source: STRINGDB
WEE1
Tchem
Family: Kinase
Novelty: 0.00162432
Score: 0.961
Data Source: Reactome,STRINGDB
ABL1
Tclin
Family: Kinase
Novelty: 0.00023803
Score: 0.952
Data Source: Reactome,STRINGDB
CDK17
Tchem
Family: Kinase
Novelty: 0.25046297
Score: 0.95
Data Source: STRINGDB
TP63
Tbio
Family: TF
Novelty: 0.00336108
Score: 0.949
Data Source: STRINGDB
CCNA2
Tchem
Novelty: 0.00049887
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.13

PubMed score by year
PubTator Score  22.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: