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Tclin
KCNG4
Potassium voltage-gated channel subfamily G member 4

Protein Summary
Description
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135). Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308251
  • ENSP00000312129
  • ENSG00000168418
  • ENST00000568181
  • ENSP00000457897

Symbol
  • KCNG3
  • KV6.3
  • KV6.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
gene perturbation
0.96
cell line
0.8
molecular function
0.79
cellular component
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.74   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.74   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Pathways (3)
Neuronal System (R-HSA-112316)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Protein-Protein Interactions (126)
1 – 10 of 126
KCNB2
Tclin
Family: IC
Novelty: 0.02629102
p_int: 0.999989269
p_ni: 2.05e-7
p_wrong: 0.000010526
Score: 0.355
Data Source: BioPlex,STRINGDB
CST2
Tbio
Novelty: 0.02114441
p_int: 0.999307415
p_ni: 0.000436279
p_wrong: 0.000256306
Score: 0.303
Data Source: BioPlex,STRINGDB
CST4
Tbio
Novelty: 0.00773554
p_int: 0.995570873
p_ni: 0.00442905
p_wrong: 7.7e-8
Score: 0.795
Data Source: BioPlex,STRINGDB
CST1
Tbio
Novelty: 0.02399609
p_int: 0.993278604
p_ni: 0.000655583
p_wrong: 0.006065813
Score: 0.552
Data Source: BioPlex,STRINGDB
KCNAB3
Tbio
Family: IC
Novelty: 0.10128237
Score: 0.938
Data Source: STRINGDB
KCNAB1
Tbio
Family: IC
Novelty: 0.01413705
Score: 0.928
Data Source: STRINGDB
KCNAB2
Tbio
Family: IC
Novelty: 0.01752175
Score: 0.917
Data Source: STRINGDB
FAU
Tbio
Novelty: 0.01170009
Score: 0.788
Data Source: STRINGDB
FAU
Tbio
Novelty: 0.01170009
Score: 0.788
Data Source: STRINGDB
GYG1
Tbio
Family: Enzyme
Novelty: 0.01446978
Score: 0.758
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.74

PubMed score by year
PubTator Score  6.08

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer