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Tbio
DLG5
Disks large homolog 5

Protein Summary
Description
Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372391
  • ENSP00000361467
  • ENSG00000151208
  • ENST00000614211
  • ENSP00000484894
  • ENSG00000274429

Symbol
  • KIAA0583
  • PDLG
  • PDLG
  • LP-DLG
  • P-DLG5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
kinase perturbation
0.88
virus perturbation
0.88
histone modification site profile
0.8
cell line
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.41   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.41   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
1
3.5
85.9
serum gamma-glutamyl transferase measurement
2
2
1
3.5
85.9
myeloid white cell count
1
1
1
45.9
myeloid white cell count
1
1
1
45.9
serum alanine aminotransferase measurement
1
1
1
11.3
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
3.5
85.9
serum gamma-glutamyl transferase measurement
1
3.5
85.9
myeloid white cell count
1
45.9
myeloid white cell count
1
45.9
serum alanine aminotransferase measurement
1
11.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
discs large MAGUK scaffold protein 5
VGNC:13053
450542
Macaque
discs large MAGUK scaffold protein 5
703123
Mouse
MGI:1918478
71228
Rat
RGD:1308753
305645
Dog
discs large MAGUK scaffold protein 5
VGNC:50873
489061
Species
Name
OMA
EggNOG
Inparanoid
Chimp
discs large MAGUK scaffold protein 5
Macaque
discs large MAGUK scaffold protein 5
Mouse
Rat
Dog
discs large MAGUK scaffold protein 5
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (70)
1 – 10 of 70
NCK1
Tbio
Novelty: 0.00352084
p_int: 0.99997523
p_ni: 0.000022655
p_wrong: 0.000002115
Data Source: BioPlex
TPM1
Tbio
Novelty: 0.00261206
p_int: 0.999377534
p_ni: 0.000050854
p_wrong: 0.000571612
Score: 0.353
Data Source: BioPlex,STRINGDB
GUK1
Tbio
Family: Kinase
Novelty: 0.00475753
Score: 0.838
Data Source: STRINGDB
SORBS3
Tbio
Novelty: 0.02412358
Score: 0.824
Data Source: STRINGDB
PARD6B
Tbio
Novelty: 0.08495161
Score: 0.692
Data Source: STRINGDB
SIPA1L3
Tbio
Novelty: 0.13962558
Score: 0.689
Data Source: STRINGDB
KIF14
Tbio
Novelty: 0.02313641
Score: 0.684
Data Source: STRINGDB
SLC22A4
Tbio
Family: Transporter
Novelty: 0.00432387
Score: 0.68
Data Source: STRINGDB
NOD2
Tclin
Novelty: 0.00059089
Score: 0.677
Data Source: STRINGDB
TCTA
Tbio
Novelty: 0.05114911
Score: 0.666
Data Source: STRINGDB
Publication Statistics
PubMed Score  69.41

PubMed score by year
PubTator Score  53.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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