Tbio DLG5 Disks large homolog 5

Protein Summary

Description

Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8TDM6
• A6H8Y3
• Q149N1
• Q5T1H7
• Q5T1H8
• Q6DKG3
• Q86WC0
• Q8TDM7
• Q9UE73
• Q9Y4E3

Gene Name

• DLG5

Ensembl ID

• ENST00000372391
• ENSP00000361467
• ENSG00000151208
• ENST00000614211
• ENSP00000484894
• ENSG00000274429

Symbol

• KIAA0583
• PDLG
• PDLG
• LP-DLG
• P-DLG5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
kinase perturbation	0.88
virus perturbation	0.88
histone modification site profile	0.8
cell line	0.79

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.41   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 87   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.41   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (6)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum gamma-glutamyl transferase measurement	EFO_0004532	ENSG00000274429	2	2	1	3.5	85.9
serum gamma-glutamyl transferase measurement	EFO_0004532	ENSG00000151208	2	2	1	3.5	85.9
myeloid white cell count	EFO_0007988	ENSG00000274429	1	1	1		45.9
myeloid white cell count	EFO_0007988	ENSG00000151208	1	1	1		45.9
serum alanine aminotransferase measurement	EFO_0004735	ENSG00000274429	1	1	1		11.3

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum gamma-glutamyl transferase measurement	EFO_0004532	1	3.5	85.9
serum gamma-glutamyl transferase measurement	EFO_0004532	1	3.5	85.9
myeloid white cell count	EFO_0007988	1		45.9
myeloid white cell count	EFO_0007988	1		45.9
serum alanine aminotransferase measurement	EFO_0004735	1		11.3

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Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	discs large MAGUK scaffold protein 5	VGNC:13053	450542
Macaque	discs large MAGUK scaffold protein 5		703123
Mouse	discs large MAGUK scaffold protein 5	MGI:1918478	71228
Rat	discs large MAGUK scaffold protein 5	RGD:1308753	305645
Dog	discs large MAGUK scaffold protein 5	VGNC:50873	489061

Species	Name	OMA	EggNOG	Inparanoid
Chimp	discs large MAGUK scaffold protein 5
Macaque	discs large MAGUK scaffold protein 5
Mouse	discs large MAGUK scaffold protein 5
Rat	discs large MAGUK scaffold protein 5
Dog	discs large MAGUK scaffold protein 5

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Gene Ontology Terms (33)

Functions (3)

Components (7)

Processes (23)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
beta-catenin binding	Inferred from Direct Assay (IDA)	MGI
cytoskeletal protein binding	Inferred from Direct Assay (IDA)	MGI
receptor signaling complex scaffold activity	Non-traceable Author Statement (NAS)	UniProtKB

Protein-Protein Interactions (70)

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1 – 10 of 70

• See Interactions on String-DB

NCK1

Tbio

Novelty: 0.00352084

p_int: 0.99997523

p_ni: 0.000022655

p_wrong: 0.000002115

Data Source: BioPlex

TPM1

Tbio

Novelty: 0.00261206

p_int: 0.999377534

p_ni: 0.000050854

p_wrong: 0.000571612

Score: 0.353

Data Source: BioPlex,STRINGDB

GUK1

Tbio

Family: Kinase

Novelty: 0.00475753

Score: 0.838

Data Source: STRINGDB

SORBS3

Tbio

Novelty: 0.02412358

Score: 0.824

Data Source: STRINGDB

PARD6B

Tbio

Novelty: 0.08495161

Score: 0.692

Data Source: STRINGDB

SIPA1L3

Tbio

Novelty: 0.13962558

Score: 0.689

Data Source: STRINGDB

KIF14

Tbio

Novelty: 0.02313641

Score: 0.684

Data Source: STRINGDB

SLC22A4

Tbio

Family: Transporter

Novelty: 0.00432387

Score: 0.68

Data Source: STRINGDB

NOD2

Tclin

Novelty: 0.00059089

Score: 0.677

Data Source: STRINGDB

TCTA

Tbio

Novelty: 0.05114911

Score: 0.666

Data Source: STRINGDB

Publication Statistics

PubMed Score  69.41

PubMed score by year

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PubTator Score  53.71

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Cell junction
Cell membrane
Cell projection
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Membrane

GWAS Trait Find Similar Targets

myeloid white cell count
serum alanine aminotransferase measurement
serum gamma-glutamyl transferase measurement

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cellular phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
nervous system phenotype
renal/urinary system phenotype