Tbio BPIFB1 BPI fold-containing family B member 1

Protein Summary

Description

May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS. The protein encoded by this gene may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. The encoded protein is secreted and is a member of the BPI/LBP/PLUNC protein superfamily. This gene is found with other members of the superfamily in a cluster on chromosome 20. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8TDL5
• A8K2H8
• Q5QP43
• Q6UWY1
• Q6ZRU7
• Q96HK6
• Q9BQP8
• Q9BWZ6
• Q9H4V6

Gene Name

• BPIFB1

Ensembl ID

• ENST00000253354
• ENSP00000253354
• ENSG00000125999

Symbol

• C20orf114
• LPLUNC1
• LPLUNC1
• C20orf114

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.58
disease perturbation	0.56
cellular component	0.46
protein complex	0.44
cell type or tissue	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.2   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.2   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0