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Tbio
RASGRP4
RAS guanyl-releasing protein 4

Protein Summary
Description
Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation. The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293062
  • ENSP00000293062
  • ENSG00000171777
  • ENST00000426920
  • ENSP00000445966
  • ENST00000433821
  • ENSP00000411878
  • ENST00000454404
  • ENSP00000416463
  • ENST00000586305
  • ENSP00000467604
  • ENST00000587738
  • ENSP00000465772
  • ENST00000587753
  • ENSP00000468483
  • ENST00000589358
  • ENSP00000465742
  • ENST00000589474
  • ENSP00000466928
  • ENST00000614135
  • ENSP00000479078
  • ENST00000615439
  • ENSP00000479844
  • ENST00000617966
  • ENSP00000479888
  • ENST00000622174
  • ENSP00000484345
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
metabolite
0.82
tissue sample
0.74
cell type or tissue
0.64
trait
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.53   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.53   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0