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Tbio
RASGRP4
RAS guanyl-releasing protein 4

Protein Summary
Description
Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation. The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293062
  • ENSP00000293062
  • ENSG00000171777
  • ENST00000426920
  • ENSP00000445966
  • ENST00000433821
  • ENSP00000411878
  • ENST00000454404
  • ENSP00000416463
  • ENST00000586305
  • ENSP00000467604
  • ENST00000587738
  • ENSP00000465772
  • ENST00000587753
  • ENSP00000468483
  • ENST00000589358
  • ENSP00000465742
  • ENST00000589474
  • ENSP00000466928
  • ENST00000614135
  • ENSP00000479078
  • ENST00000615439
  • ENSP00000479844
  • ENST00000617966
  • ENSP00000479888
  • ENST00000622174
  • ENSP00000484345
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
metabolite
0.82
tissue sample
0.74
cell type or tissue
0.64
trait
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.12   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.12   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
2
3
84.2
eosinophil count
3
2
4
80.6
basophil percentage of leukocytes
1
2
2
64.8
eosinophil percentage of leukocytes
2
1
2
41.4
neutrophil percentage of granulocytes
1
1
1
16.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
84.2
eosinophil count
4
80.6
basophil percentage of leukocytes
2
64.8
eosinophil percentage of leukocytes
2
41.4
neutrophil percentage of granulocytes
1
16.2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (25)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FCERI mediated NF-kB activation
Reactome
FLT3 Signaling
Reactome
Fc epsilon receptor (FCERI) signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FCERI mediated NF-kB activation
FLT3 Signaling
Fc epsilon receptor (FCERI) signaling
Immune System
Protein-Protein Interactions (57)
1 – 10 of 57
DUSP14
Tbio
Family: Enzyme
Novelty: 0.04013065
p_int: 0.978061364
p_ni: 0.02193713
p_wrong: 0.000001506
Score: 0.43
Data Source: BioPlex,STRINGDB
DSG4
Tbio
Novelty: 0.01599371
p_int: 0.894798958
p_ni: 0.10504819
p_wrong: 0.000152852
Data Source: BioPlex
SELENBP1
Tbio
Novelty: 0.00758018
p_int: 0.777930518
p_ni: 0.222069479
p_wrong: 4e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.965
Data Source: STRINGDB
KRAS
Tchem
Family: Enzyme
Novelty: 0.00013856
Score: 0.939
Data Source: STRINGDB
NRAS
Tchem
Family: Enzyme
Novelty: 0.00080922
Score: 0.933
Data Source: STRINGDB
RRAS2
Tbio
Family: Enzyme
Novelty: 0.01870067
Score: 0.748
Data Source: STRINGDB
RRAS
Tbio
Family: Enzyme
Novelty: 0.00786502
Score: 0.717
Data Source: STRINGDB
MRAS
Tbio
Family: Enzyme
Novelty: 0.01544981
Score: 0.703
Data Source: STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00375413
Score: 0.682
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.12

PubMed score by year
PubTator Score  7.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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