Tbio NETO1 Neuropilin and tolloid-like protein 1

Protein Summary

Description

Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity). This gene encodes a transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. This protein is thought to play a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• Q8TDF5
• Q86W85
• Q8ND78
• Q8TDF4

Gene Name

• NETO1

Ensembl ID

• ENST00000327305
• ENSP00000313088
• ENSG00000166342
• ENST00000397929
• ENSP00000381024
• ENST00000583169
• ENSP00000464312

Symbol

• BTCL1
• BCTL1
• BTCL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.99
transcription factor	0.63
transcription factor perturbation	0.61
protein domain	0.58
cell line	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.73   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 103   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.73   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0