Tbio DDX54 ATP-dependent RNA helicase DDX54

Protein Summary

Description

Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8TDD1
• Q86YT8
• Q9BRZ1

Gene Name

• DDX54

Ensembl ID

• ENST00000306014
• ENSP00000304072
• ENSG00000123064
• ENST00000314045
• ENSP00000323858

Symbol

• DP97

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
kinase perturbation	0.95
histone modification site profile	0.92
interacting protein	0.92
protein domain	0.92

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.55   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 151   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.55   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (4)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
waist-hip ratio	EFO_0004343	1	1	1		35
BMI-adjusted waist-hip ratio	EFO_0007788	1	1	1		29
body mass index	EFO_0004340	1	1	1		26.1
response to fenofibrate	GO_1901557	1	1	1		14.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
waist-hip ratio	EFO_0004343	1		35
BMI-adjusted waist-hip ratio	EFO_0007788	1		29
body mass index	EFO_0004340	1		26.1
response to fenofibrate	GO_1901557	1		14.2

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Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	DEAD-box helicase 54	VGNC:12927	739545
Macaque	DEAD-box helicase 54		712763
Mouse	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	MGI:1919240	71990
Rat	DEAD-box helicase 54	RGD:1562539	360815
Dog	DEAD-box helicase 54 [Source:HGNC Symbol;Acc:HGNC:20084]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	DEAD-box helicase 54
Macaque	DEAD-box helicase 54
Mouse	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
Rat	DEAD-box helicase 54
Dog	DEAD-box helicase 54 [Source:HGNC Symbol;Acc:HGNC:20084]

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q8TDD1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)

PathwayCommons (2)

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Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: pid	Validated nuclear estrogen receptor alpha network	65 targets	PathwayCommons: pid
PathwayCommons: pid	Validated nuclear estrogen receptor beta network	15 targets	PathwayCommons: pid

Name	Explore in Pharos	Explore in Source
Validated nuclear estrogen receptor alpha network	65 targets	PathwayCommons: pid
Validated nuclear estrogen receptor beta network	15 targets	PathwayCommons: pid

Gene Ontology Terms (13)

Functions (6)

Components (4)

Processes (3)

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1 – 6 of 6

GO Term	Evidence	Assigned by
ATP-dependent RNA helicase activity	Inferred from Direct Assay (IDA)	UniProtKB
estrogen receptor binding	Inferred from Direct Assay (IDA)	UniProtKB
signaling receptor binding	Inferred from Direct Assay (IDA)	UniProtKB
transcription corepressor activity	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (324)

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1 – 10 of 324

• See Interactions on String-DB

GRPEL2

Tdark

Novelty:  0.52660174

p_int:  0.999935151

p_ni:  0.000059852

p_wrong:  0.000004997

Data Source:  BioPlex

ZNF579

Tdark

Family:  TF

Novelty:  4.75515836

p_int:  0.999766447

p_ni:  0.000233553

Data Source:  BioPlex

PHF10

Tbio

Family:  Epigenetic

Novelty:  0.05941323

p_int:  0.999685593

p_ni:  0.000314371

p_wrong:  3.6e-8

Data Source:  BioPlex

YY1AP1

Tbio

Novelty:  0.06862573

p_int:  0.999170287

p_ni:  0.000829573

p_wrong:  1.41e-7

Data Source:  BioPlex

C1QBP

Tbio

Novelty:  0.00532825

p_int:  0.998845048

p_ni:  0.001154952

Data Source:  BioPlex

DHX57

Tdark

Family:  Enzyme

Novelty:  0.8244078

p_int:  0.998601677

p_ni:  0.001398323

Score:  0.633

Data Source:  BioPlex,STRINGDB

ZNF638

Tbio

Novelty:  0.13248064

p_int:  0.9978165

p_ni:  0.0021835

Data Source:  BioPlex

RRP8

Tbio

Family:  Enzyme

Novelty:  0.04922797

p_int:  0.99612773

p_ni:  0.00387227

Score:  0.922

Data Source:  BioPlex,STRINGDB

RNF220

Tbio

Family:  Enzyme

Novelty:  0.14024436

p_int:  0.995731338

p_ni:  0.000405472

p_wrong:  0.00386319

Data Source:  BioPlex

PDGFB

Tbio

Novelty:  0.00080876

p_int:  0.995020906

p_ni:  0.004979094

Data Source:  BioPlex

Publication Statistics

PubMed Score  8.55

PubMed score by year

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PubTator Score  3.33

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
ATP-binding
Complete proteome
Helicase
Hydrolase
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist-hip ratio
body mass index
response to fenofibrate
waist-hip ratio

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
embryo phenotype
growth/size/body region phenotype
hematopoietic system phenotype
immune system phenotype
mortality/aging