DDX54
ATP-dependent RNA helicase DDX54
Protein Summary
Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000306014
- ENSP00000304072
- ENSG00000123064
- ENST00000314045
- ENSP00000323858
- DP97
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 1 | ||
kinase perturbation | 0.95 | ||
histone modification site profile | 0.92 | ||
interacting protein | 0.92 | ||
protein domain | 0.92 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.55 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 151 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.55 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 151 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (324)
GRPEL2
Novelty: 0.52660174
p_int: 0.999935151
p_ni: 0.000059852
p_wrong: 0.000004997
Data Source: BioPlex
PHF10
Family: Epigenetic
Novelty: 0.05941323
p_int: 0.999685593
p_ni: 0.000314371
p_wrong: 3.6e-8
Data Source: BioPlex
YY1AP1
Novelty: 0.06862573
p_int: 0.999170287
p_ni: 0.000829573
p_wrong: 1.41e-7
Data Source: BioPlex
DHX57
Family: Enzyme
Novelty: 0.8244078
p_int: 0.998601677
p_ni: 0.001398323
Score: 0.633
Data Source: BioPlex,STRINGDB
RRP8
Family: Enzyme
Novelty: 0.04922797
p_int: 0.99612773
p_ni: 0.00387227
Score: 0.922
Data Source: BioPlex,STRINGDB
RNF220
Family: Enzyme
Novelty: 0.14024436
p_int: 0.995731338
p_ni: 0.000405472
p_wrong: 0.00386319
Data Source: BioPlex
Nearest Tclin Targets
Pathways (2)
PathwayCommons (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: pid | Validated nuclear estrogen receptor alpha network | ||||
PathwayCommons: pid | Validated nuclear estrogen receptor beta network | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Validated nuclear estrogen receptor alpha network | ||||
Validated nuclear estrogen receptor beta network | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (6)
Components (4)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
waist-hip ratio | 1 | 1 | 1 | 35 | |||||
BMI-adjusted waist-hip ratio | 1 | 1 | 1 | 29 | |||||
body mass index | 1 | 1 | 1 | 26.1 | |||||
response to fenofibrate | 1 | 1 | 1 | 14.2 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
waist-hip ratio | 1 | 35 | |||||
BMI-adjusted waist-hip ratio | 1 | 29 | |||||
body mass index | 1 | 26.1 | |||||
response to fenofibrate | 1 | 14.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | DEAD-box helicase 54 | VGNC:12927 | 739545 | |||||
Macaque | DEAD-box helicase 54 | 712763 | ||||||
Mouse | MGI:1919240 | 71990 | ||||||
Rat | RGD:1562539 | 360815 | ||||||
Dog | DEAD-box helicase 54 [Source:HGNC Symbol;Acc:HGNC:20084] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | DEAD-box helicase 54 | |||||
Macaque | DEAD-box helicase 54 | |||||
Mouse | ||||||
Rat | ||||||
Dog | DEAD-box helicase 54 [Source:HGNC Symbol;Acc:HGNC:20084] | |||||
Publication Statistics
PubMed Score 8.55
PubMed score by year
PubTator Score 3.33
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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