Tbio DDX54 ATP-dependent RNA helicase DDX54

Protein Summary

Description

Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8TDD1
• Q86YT8
• Q9BRZ1

Gene Name

• DDX54

Ensembl ID

• ENST00000306014
• ENSP00000304072
• ENSG00000123064
• ENST00000314045
• ENSP00000323858

Symbol

• DP97

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
kinase perturbation	0.95
histone modification site profile	0.92
interacting protein	0.92
protein domain	0.92

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.44   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 151   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.44   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0