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Tbio
DDX54
ATP-dependent RNA helicase DDX54

Protein Summary
Description
Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306014
  • ENSP00000304072
  • ENSG00000123064
  • ENST00000314045
  • ENSP00000323858

Symbol
  • DP97
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
kinase perturbation
0.95
histone modification site profile
0.92
interacting protein
0.92
protein domain
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.55   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.55   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
1
1
35
BMI-adjusted waist-hip ratio
1
1
1
29
body mass index
1
1
1
26.1
response to fenofibrate
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
35
BMI-adjusted waist-hip ratio
1
29
body mass index
1
26.1
response to fenofibrate
1
14.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 54
VGNC:12927
739545
Macaque
DEAD-box helicase 54
712763
Mouse
MGI:1919240
71990
Rat
RGD:1562539
360815
Dog
DEAD-box helicase 54 [Source:HGNC Symbol;Acc:HGNC:20084]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 54
Macaque
DEAD-box helicase 54
Mouse
Rat
Dog
DEAD-box helicase 54 [Source:HGNC Symbol;Acc:HGNC:20084]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TDD1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Validated nuclear estrogen receptor alpha network
PathwayCommons: pid
Validated nuclear estrogen receptor beta network
Name
Explore in Pharos
Explore in Source
Validated nuclear estrogen receptor alpha network
Validated nuclear estrogen receptor beta network
Gene Ontology Terms (13)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (324)
1 – 10 of 324
GRPEL2
Tdark
Novelty:  0.52660174
p_int:  0.999935151
p_ni:  0.000059852
p_wrong:  0.000004997
Data Source:  BioPlex
ZNF579
Tdark
Family:  TF
Novelty:  4.75515836
p_int:  0.999766447
p_ni:  0.000233553
Data Source:  BioPlex
PHF10
Tbio
Family:  Epigenetic
Novelty:  0.05941323
p_int:  0.999685593
p_ni:  0.000314371
p_wrong:  3.6e-8
Data Source:  BioPlex
YY1AP1
Tbio
Novelty:  0.06862573
p_int:  0.999170287
p_ni:  0.000829573
p_wrong:  1.41e-7
Data Source:  BioPlex
C1QBP
Tbio
Novelty:  0.00532825
p_int:  0.998845048
p_ni:  0.001154952
Data Source:  BioPlex
DHX57
Tdark
Family:  Enzyme
Novelty:  0.8244078
p_int:  0.998601677
p_ni:  0.001398323
Score:  0.633
Data Source:  BioPlex,STRINGDB
ZNF638
Tbio
Novelty:  0.13248064
p_int:  0.9978165
p_ni:  0.0021835
Data Source:  BioPlex
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.99612773
p_ni:  0.00387227
Score:  0.922
Data Source:  BioPlex,STRINGDB
RNF220
Tbio
Family:  Enzyme
Novelty:  0.14024436
p_int:  0.995731338
p_ni:  0.000405472
p_wrong:  0.00386319
Data Source:  BioPlex
PDGFB
Tbio
Novelty:  0.00080876
p_int:  0.995020906
p_ni:  0.004979094
Data Source:  BioPlex
Publication Statistics
PubMed Score  8.55

PubMed score by year
PubTator Score  3.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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