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Tchem
BRSK1
Serine/threonine-protein kinase BRSK1

Protein Summary
Description
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, prob ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309383
  • ENSP00000310649
  • ENSG00000160469
  • ENST00000585418
  • ENSP00000467357
  • ENST00000590333
  • ENSP00000468190

Symbol
  • KIAA1811
  • SAD1
  • SADB
  • hSAD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.85
cellular component
0.64
tissue sample
0.59
biological process
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.69   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 412   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.69   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 412   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
1
1
1
64.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
1
64.2
Gene Ontology Terms (31)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred by Curator (IC)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (67)
1 – 10 of 67
CAB39
Tbio
Novelty: 0.01592402
Score: 0.953
Data Source: STRINGDB
MAPT
Tchem
Novelty: 0.00013232
Score: 0.934
Data Source: STRINGDB
STRADA
Tbio
Family: Kinase
Novelty: 0.0190243
Score: 0.928
Data Source: STRINGDB
STK11
Tchem
Family: Kinase
Novelty: 0.00073247
Score: 0.928
Data Source: STRINGDB
MAP2
Tchem
Novelty: 0.00068493
Score: 0.917
Data Source: STRINGDB
STRADB
Tbio
Family: Kinase
Novelty: 0.03532206
Score: 0.901
Data Source: STRINGDB
CDC25B
Tchem
Family: Enzyme
Novelty: 0.00378458
Score: 0.764
Data Source: STRINGDB
HSPBP1
Tbio
Novelty: 0.01176285
Score: 0.754
Data Source: STRINGDB
CDC25C
Tchem
Family: Enzyme
Novelty: 0.00227769
Score: 0.728
Data Source: STRINGDB
CDR2
Tbio
Novelty: 0.00141419
Score: 0.712
Data Source: STRINGDB
Publication Statistics
PubMed Score  40.69

PubMed score by year
PubTator Score  40.32

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer