Protein Classes
Protein Summary
Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. The protein encoded by this gene is specifically expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. [provided by RefSeq, Apr 2012]
- ENST00000297130
- ENSP00000297130
- ENSG00000164591
- ENST00000517768
- ENSP00000428815
- ENST00000615557
- ENSP00000478375
- FRP3
- CS3
- CS-3
- FRP3
- FATZ-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
co-expressed gene | 0.65 | ||
small molecule perturbation | 0.64 | ||
tissue sample | 0.59 | ||
cell line | 0.52 | ||
microRNA | 0.49 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.06 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 25 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.06 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 25 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Gene Ontology Terms (5)
Functions (3)
Components (2)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (21)
1 – 10 of 21
LDB3
Novelty: 0.00093894
Score: 0.872
Data Source: STRINGDB
FLNC
Novelty: 0.00112022
Score: 0.816
Data Source: STRINGDB
ACTN2
Novelty: 0.00993205
Score: 0.815
Data Source: STRINGDB
TCAP
Novelty: 0.00664743
Score: 0.781
Data Source: STRINGDB
ACTN1
Novelty: 0.01041776
Score: 0.77
Data Source: STRINGDB
SYNPO
Novelty: 0.00583594
Score: 0.647
Data Source: STRINGDB
MAPKAPK3
Family: Kinase
Novelty: 0.01845634
Score: 0.595
Data Source: STRINGDB
MYOT
Novelty: 0.01053217
Score: 0.53
Data Source: STRINGDB
RBM22
Novelty: 0.09993655
Score: 0.501
Data Source: STRINGDB
MYBPC2
Novelty: 0.44152431
Score: 0.497
Data Source: STRINGDB
Publication Statistics
PubMed Score 3.06
PubMed score by year
PubTator Score 128.75
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MIPKEQKGPVMAAMGDLTEPVPTLDLGKKLSVPQDLMMEELSLRNNRGSLLFQKRQRRVQKFTFELAASQ
1-70
RAMLAGSARRKVTGTAESGTVANANGPEGPNYRSELHIFPASPGASLGGPEGAHPAAAPAGCVPSPSALA
70-140
PGYAEPLKGVPPEKFNHTAISKGYRCPWQEFVSYRDYQSDGRSHTPSPNDYRNFNKTPVPFGGPLVGGTF
140-210
PRPGTPFIPEPLSGLELLRLRPSFNRVAQGWVRNLPESEEL
210-251
MIPKEQKGPVMAAMGDLTEPVPTLDLGKKLSVPQDLMMEELSLRNNRGSLLFQKRQRRVQKFTFELAASQRAMLAGSARRKVTGTAESGTVANANGPEGPNYRSELHIFPASPGASLGGPEGAHPAAAPAGCVPSPSALAPGYAEPLKGVPPEKFNHTAISKGYRCPWQEFVSYRDYQSDGRSHTPSPNDYRNFNKTPVPFGGPLVGGTFPRPGTPFIPEPLSGLELLRLRPSFNRVAQGWVRNLPESEEL
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