You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KLF14
Krueppel-like factor 14

Protein Summary
Description
This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000583337
  • ENSP00000463287
  • ENSG00000266265

Symbol
  • BTEB5
  • BTEB5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.67
cell type or tissue
0.6
transcription factor
0.55
gene perturbation
0.47
PubMedID
0.4


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.2   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.2   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
11
9
21
97.6
triglyceride measurement
7
8
17
97.1
5
5
3
1.1
96.4
BMI-adjusted waist-hip ratio
2
2
2
84.6
low density lipoprotein cholesterol measurement
1
1
1
50.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
21
97.6
triglyceride measurement
17
97.1
3
1.1
96.4
BMI-adjusted waist-hip ratio
2
84.6
low density lipoprotein cholesterol measurement
1
50.7
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Kruppel like factor 14
VGNC:14031
735419
Macaque
Kruppel like factor 14
703887
Mouse
MGI:3577024
619665
Rat
RGD:1306012
312203
Dog
Kruppel like factor 14
VGNC:42433
482254
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Kruppel like factor 14
Macaque
Kruppel like factor 14
Mouse
Rat
Dog
Kruppel like factor 14
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TD94-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (49)
1 – 10 of 49
SIN3A
Tbio
Novelty: 0.00747207
Score: 0.66
Data Source: STRINGDB
ZFAND6
Tbio
Novelty: 0.08904571
Score: 0.634
Data Source: STRINGDB
DEGS1
Tchem
Family: Enzyme
Novelty: 0.00300325
Score: 0.623
Data Source: STRINGDB
ARAP1
Tbio
Novelty: 0.0479494
Score: 0.593
Data Source: STRINGDB
ZBED3
Tbio
Family: TF
Novelty: 0.13746475
Score: 0.589
Data Source: STRINGDB
AGPAT5
Tbio
Family: Enzyme
Novelty: 0.23785857
Score: 0.58
Data Source: STRINGDB
TCF7L2
Tbio
Family: TF
Novelty: 0.00178694
Score: 0.573
Data Source: STRINGDB
FOXP3
Tbio
Family: TF
Novelty: 0.00017205
Score: 0.573
Data Source: STRINGDB
CDKAL1
Tbio
Family: Enzyme
Novelty: 0.01013607
Score: 0.568
Data Source: STRINGDB
USP26
Tbio
Family: Enzyme
Novelty: 0.02916691
Score: 0.565
Data Source: STRINGDB
Publication Statistics
PubMed Score  42.20

PubMed score by year
PubTator Score  19.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: