Tbio MAGEC3 Melanoma-associated antigen C3

Protein Summary

Description

This gene is a member of the MAGEC gene family. The members of this family are not expressed in normal tissues, except for testis, and are expressed in tumors of various histological types. The MAGEC genes are clustered on chromosome Xq26-q27. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8TD91
• Q3SYA7
• Q5JZ43
• Q9BZ80

Gene Name

• MAGEC3

Ensembl ID

• ENST00000298296
• ENSP00000298296
• ENSG00000165509
• ENST00000409007
• ENSP00000386566
• ENST00000544766
• ENSP00000440444

Symbol

• HCA2
• HCA2
• CT7.2
• MAGEC4
• MAGE-C3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.85
cellular component	0.75
cell line	0.49
tissue	0.43
gene perturbation	0.34

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Melanoma-associated Antigen C3

DTO Classes

Protein / Cell Adhesion / Melanoma-associated Antigen C3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.28   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 59   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.28   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0