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Tbio
DSCAML1
Down syndrome cell adhesion molecule-like protein 1

Protein Summary
Description
Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed:11453658). Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). The protein encoded by this gene is a member of the Ig superfamily of cell adhesion molecules and is involved in neuronal differentiation. The encoded membrane-bound protein localizes to the cell surface, where it forms aggregates that repel neuronal processes of the same cell type. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000527706
  • ENSP00000434335
  • ENSG00000177103

Symbol
  • DSCAM2
  • KIAA1132
  • DSCAM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
trait
0.75
tissue sample
0.68
phenotype
0.57
cell line
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.15   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 21   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.15   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
PPFIA3
Tbio
Novelty:  0.03837299
Score:  0.669
Data Source:  STRINGDB
NTN1
Tbio
Novelty:  0.00183678
Score:  0.655
Data Source:  STRINGDB
APOA5
Tbio
Novelty:  0.00232222
Score:  0.647
Data Source:  STRINGDB
VSTM5
Tdark
Novelty:  0.62835441
Score:  0.592
Data Source:  STRINGDB
NKAIN2
Tbio
Family:  Enzyme
Novelty:  0.07079906
Score:  0.578
Data Source:  STRINGDB
NTN5
Tdark
Novelty:  0.59518421
Score:  0.559
Data Source:  STRINGDB
SYT2
Tbio
Novelty:  0.00754735
Score:  0.536
Data Source:  STRINGDB
CPA1
Tchem
Family:  Enzyme
Novelty:  0.00601525
Score:  0.535
Data Source:  STRINGDB
FLRT1
Tdark
Novelty:  0.23047852
Score:  0.532
Data Source:  STRINGDB
OPN4
Tbio
Family:  GPCR
Novelty:  0.00105995
Score:  0.531
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
DSCAM interactions
Reactome
Developmental Biology
Reactome
Netrin-1 signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
DSCAM interactions
Developmental Biology
Netrin-1 signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
5
5
92.7
apolipoprotein A 1 measurement
2
2
2
77.8
Myopia
2
2
0
4.3
71.8
refractive error measurement
2
2
1
7.5
71.8
putamen volume
1
1
0
8.4
68
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
5
92.7
apolipoprotein A 1 measurement
2
77.8
Myopia
0
4.3
71.8
refractive error measurement
1
7.5
71.8
putamen volume
0
8.4
68
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DS cell adhesion molecule like 1
VGNC:10394
451577
Mouse
MGI:2150309
114873
Rat
RGD:1304887
315615
Dog
DS cell adhesion molecule like 1
489388
Horse
DS cell adhesion molecule like 1
102149147
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DS cell adhesion molecule like 1
Mouse
Rat
Dog
DS cell adhesion molecule like 1
Horse
DS cell adhesion molecule like 1
Publication Statistics
PubMed Score 34.15
PubMed score by year
PubTator Score 4.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title