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Tdark
DNAH3
Dynein heavy chain 3, axonemal

Protein Summary
Description
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261383
  • ENSP00000261383
  • ENSG00000158486

Symbol
  • DNAHC3B
  • HDHC8
  • HEL-36
  • DNAHC3B
  • HSADHC3
  • DNAHC3-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
molecular function
0.91
cell type or tissue
0.74
tissue sample
0.63
histone modification site profile
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.92   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.92   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
1
1
24.1
platelet crit
1
1
1
9.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
24.1
platelet crit
1
9.5
Gene Ontology Terms (12)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (85)
1 – 10 of 85
PAFAH1B1
Tbio
Family: Enzyme
Novelty: 0.00256206
Score: 0.941
Data Source: STRINGDB
DCTN1
Tbio
Novelty: 0.00494896
Score: 0.938
Data Source: STRINGDB
DCTN2
Tbio
Novelty: 0.01045432
Score: 0.938
Data Source: STRINGDB
DYNC1LI1
Tbio
Novelty: 0.02164556
Score: 0.938
Data Source: STRINGDB
CLIP1
Tbio
Novelty: 0.00399891
Score: 0.935
Data Source: STRINGDB
DYNLT3
Tbio
Novelty: 0.10969629
Score: 0.934
Data Source: STRINGDB
DNAH17
Tdark
Novelty: 0.14878692
Score: 0.922
Data Source: STRINGDB
DNAH1
Tbio
Novelty: 0.0369386
Score: 0.918
Data Source: STRINGDB
DNAH8
Tbio
Novelty: 0.10883442
Score: 0.918
Data Source: STRINGDB
DNAH5
Tbio
Novelty: 0.01579144
Score: 0.917
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.92

PubMed score by year
PubTator Score  3.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer