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Tdark
DNAH3
Dynein heavy chain 3, axonemal

Protein Summary
Description
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261383
  • ENSP00000261383
  • ENSG00000158486

Symbol
  • DNAHC3B
  • HDHC8
  • HEL-36
  • DNAHC3B
  • HSADHC3
  • DNAHC3-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
molecular function
0.91
cell type or tissue
0.74
tissue sample
0.63
histone modification site profile
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.89   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.89   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
PAFAH1B1
Tbio
Family:  Enzyme
Novelty:  0.00256206
Score:  0.941
Data Source:  STRINGDB
DCTN1
Tbio
Novelty:  0.00494896
Score:  0.938
Data Source:  STRINGDB
DCTN2
Tbio
Novelty:  0.01045432
Score:  0.938
Data Source:  STRINGDB
DYNC1LI1
Tbio
Novelty:  0.02164556
Score:  0.938
Data Source:  STRINGDB
CLIP1
Tbio
Novelty:  0.00399891
Score:  0.935
Data Source:  STRINGDB
DYNLT3
Tbio
Novelty:  0.10969629
Score:  0.934
Data Source:  STRINGDB
DNAH17
Tdark
Novelty:  0.14878692
Score:  0.922
Data Source:  STRINGDB
DNAH1
Tbio
Novelty:  0.0369386
Score:  0.918
Data Source:  STRINGDB
DNAH8
Tbio
Novelty:  0.10883442
Score:  0.918
Data Source:  STRINGDB
DNAH5
Tbio
Novelty:  0.01579144
Score:  0.917
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
75.4
eosinophil percentage of leukocytes
1
1
1
61.4
platelet crit
1
1
1
31.4
urate measurement
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
75.4
eosinophil percentage of leukocytes
1
61.4
platelet crit
1
31.4
urate measurement
1
29
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein axonemal heavy chain 3
VGNC:8978
453978
Macaque
dynein axonemal heavy chain 3
697227
Mouse
MGI:2683040
381917
Dog
dynein axonemal heavy chain 3
VGNC:40015
489981
Horse
dynein axonemal heavy chain 3
VGNC:49424
100059138
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein axonemal heavy chain 3
Macaque
dynein axonemal heavy chain 3
Mouse
Dog
dynein axonemal heavy chain 3
Horse
dynein axonemal heavy chain 3
Publication Statistics
PubMed Score 14.89
PubMed score by year
PubTator Score 3.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title