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Tchem
TRPM4
Transient receptor potential cation channel subfamily M member 4

Protein Summary
Description
Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:29211723). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production throug ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252826
  • ENSP00000252826
  • ENSG00000130529
  • ENST00000427978
  • ENSP00000407492

Symbol
  • LTRPC4
  • LTrpC4
  • PFHB1B
  • TRPM4B
  • hTRPM4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
biological process
0.72
gene perturbation
0.68
cell line
0.66
tissue sample
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 315.8   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 315.8   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (16)
spermine
Rendered image for spermine
ADP
Rendered image for ADP
PIP<sub>2</sub>
Rendered image for PIP<sub>2</sub>
BTP2
Rendered image for BTP2
CHEMBL4863993
Rendered image for CHEMBL4863993
decavanadate
Rendered image for decavanadate
AMP-PNP
Rendered image for AMP-PNP
Protein-Protein Interactions (83)
GLO1
Tchem
Family:  Enzyme
Novelty:  0.00225012
p_int:  0.999992813
p_ni:  0.000007181
p_wrong:  7e-9
Data Source:  BioPlex
CCDC107
Tdark
Novelty:  1.10682722
p_int:  0.999962439
p_ni:  0.000035795
p_wrong:  0.000001766
Score:  0.158
Data Source:  BioPlex,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999960975
p_ni:  0.000039022
p_wrong:  3e-9
Data Source:  BioPlex
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.999958641
p_ni:  0.000040983
p_wrong:  3.77e-7
Data Source:  BioPlex
TRPM8
Tclin
Family:  IC
Novelty:  0.00153949
p_int:  0.999948954
p_ni:  0.000051045
p_wrong:  1e-9
Score:  0.303
Data Source:  BioPlex,STRINGDB
FNDC4
Tbio
Novelty:  0.31597146
p_int:  0.999869528
p_ni:  0.000129503
p_wrong:  9.69e-7
Score:  0.223
Data Source:  BioPlex,STRINGDB
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.999868217
p_ni:  0.000131782
p_wrong:  1e-9
Data Source:  BioPlex
IFT57
Tbio
Novelty:  0.03373199
p_int:  0.999637666
p_ni:  0.000237662
p_wrong:  0.000124672
Data Source:  BioPlex
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.998505541
p_ni:  0.001201089
p_wrong:  0.00029337
Data Source:  BioPlex
SCN5A
Tclin
Family:  IC
Novelty:  0.00050944
Score:  0.875
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
TRP channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
TRP channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (43)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
2
1
2
78.8
mean arterial pressure
1
1
1
43.2
electrocardiography
1
1
3
34.8
pulse pressure measurement
1
1
1
22.8
body weight
1
1
1
22.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
2
78.8
mean arterial pressure
1
43.2
electrocardiography
3
34.8
pulse pressure measurement
1
22.8
body weight
1
22.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily M member 4
VGNC:13103
456197
Macaque
transient receptor potential cation channel subfamily M member 4
719120
Mouse
MGI:1915917
68667
Rat
RGD:620244
171143
Dog
transient receptor potential cation channel subfamily M member 4
VGNC:47875
484385
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily M member 4
Macaque
transient receptor potential cation channel subfamily M member 4
Mouse
Rat
Dog
transient receptor potential cation channel subfamily M member 4
Publication Statistics
PubMed Score 315.80
PubMed score by year
PubTator Score 124.64
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title