GPT2
Alanine aminotransferase 2
Protein Summary
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
- ENST00000340124
- ENSP00000345282
- ENSG00000166123
- ENST00000440783
- ENSP00000413804
- AAT2
- ALT2
- ALT2
- GPT 2
- MRT49
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.97 | ||
hub protein | 0.96 | ||
transcription factor perturbation | 0.96 | ||
transcription factor binding site profile | 0.82 | ||
small molecule perturbation | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 466.98 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 196 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 466.98 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 196 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0