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Tbio
GPT2
Alanine aminotransferase 2

Protein Summary
Description
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340124
  • ENSP00000345282
  • ENSG00000166123
  • ENST00000440783
  • ENSP00000413804

Symbol
  • AAT2
  • ALT2
  • ALT2
  • GPT 2
  • MRT49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
hub protein
0.96
transcription factor perturbation
0.96
transcription factor binding site profile
0.82
small molecule perturbation
0.77


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.92   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.92   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamic--pyruvic transaminase 2
VGNC:13712
465145
Macaque
glutamic--pyruvic transaminase 2
716305
Mouse
MGI:1915391
108682
Horse
glutamic--pyruvic transaminase 2
VGNC:18563
100056741
Cow
glutamic--pyruvic transaminase 2
VGNC:29617
618400
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamic--pyruvic transaminase 2
Macaque
glutamic--pyruvic transaminase 2
Mouse
Horse
glutamic--pyruvic transaminase 2
Cow
glutamic--pyruvic transaminase 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8TD30-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Alanine metabolism (R-HSA-8964540)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Alanine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Alanine metabolism
Metabolism
Metabolism of amino acids and derivatives
Protein-Protein Interactions (121)
1 – 10 of 121
THEM4
Tbio
Family: Enzyme
Novelty: 0.0191855
p_int: 0.999999993
p_ni: 6e-9
p_wrong: 1e-9
Score: 0.214
Data Source: BioPlex,STRINGDB
PLA2G10
Tchem
Family: Enzyme
Novelty: 0.00289317
p_int: 0.999999767
p_ni: 2.13e-7
p_wrong: 2e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
THEM5
Tbio
Family: Enzyme
Novelty: 0.20267249
p_int: 0.999999418
p_ni: 5.82e-7
Data Source: BioPlex
GPT
Tbio
Family: Enzyme
Novelty: 0.00003498
p_int: 0.999996993
p_wrong: 0.000003007
Score: 0.81
Data Source: BioPlex,STRINGDB
GPHA2
Tbio
Novelty: 0.01057969
p_int: 0.99991993
p_ni: 0.000080033
p_wrong: 3.7e-8
Score: 0.303
Data Source: BioPlex,STRINGDB
CLPX
Tbio
Family: Enzyme
Novelty: 0.00254331
p_int: 0.999544037
p_ni: 0.000455963
Data Source: BioPlex
CPT2
Tchem
Family: Enzyme
Novelty: 0.00345645
p_int: 0.982424769
p_ni: 0.017575231
Score: 0.468
Data Source: BioPlex,STRINGDB
GOT1
Tbio
Family: Enzyme
Novelty: 0.00448817
Score: 0.983
Data Source: STRINGDB
GLUD1
Tbio
Family: Enzyme
Novelty: 0.00301109
Score: 0.966
Data Source: STRINGDB
GOT2
Tbio
Family: Enzyme
Novelty: 0.00054023
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  203.92

PubMed score by year
PubTator Score  76.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer