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Tdark
SFXN5
Sideroflexin-5

Protein Summary
Description
Transports citrate. Potential iron transporter (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272433
  • ENSP00000272433
  • ENSG00000144040

Symbol
  • BBG-TCC
  • SLC56A5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
transcription factor binding site profile
0.82
tissue sample
0.6
transcription factor
0.59
histone modification site profile
0.56


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.09   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.09   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
2
3
81.4
intelligence
3
4
3
6.3
60.8
4
2
1
1.1
55.8
glomerular filtration rate
1
1
1
47.7
self reported educational attainment
2
2
2
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
3
81.4
intelligence
3
6.3
60.8
1
1.1
55.8
glomerular filtration rate
1
47.7
self reported educational attainment
2
40.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sideroflexin 5
VGNC:10757
459320
Macaque
sideroflexin 5
705559
Mouse
MGI:2137681
94282
Rat
RGD:628706
261737
Dog
sideroflexin 5
VGNC:46090
612350
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sideroflexin 5
Macaque
sideroflexin 5
Mouse
Rat
Dog
sideroflexin 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TD22-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (55)
1 – 10 of 55
LAMP2
Tbio
Novelty:  0.00168009
p_int:  0.999752822
p_ni:  0.000247178
Data Source:  BioPlex
SLC6A15
Tchem
Family:  Transporter
Novelty:  0.04011524
p_int:  0.999468
p_ni:  0.000532
Score:  0.152
Data Source:  BioPlex,STRINGDB
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.994752332
p_ni:  0.00521371
p_wrong:  0.000033958
Data Source:  BioPlex
SLC39A9
Tbio
Family:  Transporter
Novelty:  0.06143625
p_int:  0.99244901
p_ni:  0.007550978
p_wrong:  1.2e-8
Score:  0.229
Data Source:  BioPlex,STRINGDB
SLC5A5
Tbio
Family:  Transporter
Novelty:  0.00139132
p_int:  0.988350109
p_ni:  0.011649887
p_wrong:  4e-9
Data Source:  BioPlex
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
p_int:  0.978827499
p_ni:  0.020654476
p_wrong:  0.000518025
Data Source:  BioPlex
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.975520404
p_ni:  0.024479586
p_wrong:  1e-8
Data Source:  BioPlex
TMEM108
Tbio
Novelty:  0.08687599
p_int:  0.975058685
p_ni:  0.023710935
p_wrong:  0.001230381
Data Source:  BioPlex
TNF
Tclin
Novelty:  0.00001457
p_int:  0.974090509
p_ni:  0.024865901
p_wrong:  0.00104359
Data Source:  BioPlex
PON1
Tbio
Family:  Enzyme
Novelty:  0.00033137
p_int:  0.974065425
p_ni:  0.025934562
p_wrong:  1.3e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  3.09

PubMed score by year
PubTator Score  1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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