Tbio SLC2A12 Solute carrier family 2, facilitated glucose transporter member 12

Protein Classes

PANTHER Classes

Protein / ... / Carbohydrate Transporter / Solute Carrier Family 2, Facilitated Glucose Transporter Member 12

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc2 Family Of Hexose And Sugar Alcohol Transporters / Class Ii Transporters / Solute Carrier Family 2, Facilitated Glucose Transporter Member 12

Protein Summary

Description

Facilitative glucose transporter. SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8TD20
• B3KV17
• Q7Z6U3
• Q96MR8

Gene Name

• SLC2A12

Ensembl ID

• ENST00000275230
• ENSP00000275230
• ENSG00000146411

Symbol

• GLUT12
• GLUT8
• GLUT8
• GLUT12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.74
gene perturbation	0.68
protein domain	0.58
microRNA	0.54
transcription factor perturbation	0.54

Related Tools

RESOLUTE

RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.57   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 109   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.57   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
coronary artery disease	EFO_0001645	6	2	3	1.1	92.4
hemoglobin measurement	EFO_0004509	2	2	2		62.6
creatinine measurement	EFO_0004518	1	1	1		58.4
glomerular filtration rate	EFO_0005208	1	1	1		57.3
Diuretic use measurement	EFO_0009928	1	1	1		47.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
coronary artery disease	EFO_0001645	3	1.1	92.4
hemoglobin measurement	EFO_0004509	2		62.6
creatinine measurement	EFO_0004518	1		58.4
glomerular filtration rate	EFO_0005208	1		57.3
Diuretic use measurement	EFO_0009928	1		47.7

Reset Zoom  Beta Count   Odds Ratio

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 2 member 12	VGNC:7925	472131
Macaque	solute carrier family 2 member 12		707255
Mouse	solute carrier family 2 (facilitated glucose transporter), member 12	MGI:3052471	353169
Rat	solute carrier family 2 member 12	RGD:1310175	308028
Dog	solute carrier family 2 member 12	VGNC:46339	483994

Species	Name	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 2 member 12
Macaque	solute carrier family 2 member 12
Mouse	solute carrier family 2 (facilitated glucose transporter), member 12
Rat	solute carrier family 2 member 12
Dog	solute carrier family 2 member 12

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q8TD20-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)

Reactome (3)

WikiPathways (4)

Cellular hexose transport (R-HSA-189200)

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Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cellular hexose transport	21 targets	R-HSA-189200
Reactome	SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
Cellular hexose transport	21 targets	R-HSA-189200
SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Transport of small molecules	725 targets	R-HSA-382551

Gene Ontology Terms (7)

Functions (2)

Components (4)

Processes (1)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
carbohydrate:proton symporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
D-glucose transmembrane transporter activity	Traceable Author Statement (TAS)	Reactome

Protein-Protein Interactions (105)

Explore Interacting Targets

1 – 10 of 105

• See Interactions on String-DB

TMEM242

Tdark

Novelty:  0.99055845

p_int:  0.999933724

p_ni:  0.000064468

p_wrong:  0.000001808

Score:  0.179

Data Source:  BioPlex,STRINGDB

TAMM41

Tbio

Family:  Enzyme

Novelty:  0.06004824

p_int:  0.999459163

p_ni:  0.000540837

p_wrong:  1e-9

Score:  0.245

Data Source:  BioPlex,STRINGDB

MTFR2

Tbio

Novelty:  0.20272025

p_int:  0.999424357

p_ni:  0.000394648

p_wrong:  0.000180995

Data Source:  BioPlex

ORMDL2

Tdark

Novelty:  0.37598406

p_int:  0.998772392

p_ni:  0.000794159

p_wrong:  0.000433448

Score:  0.156

Data Source:  BioPlex,STRINGDB

SLC25A23

Tbio

Family:  Transporter

Novelty:  0.10446757

p_int:  0.997800051

p_ni:  0.002192653

p_wrong:  0.000007296

Score:  0.288

Data Source:  BioPlex,STRINGDB

SLC25A28

Tbio

Family:  Transporter

Novelty:  0.05050869

p_int:  0.996523301

p_ni:  0.00012675

p_wrong:  0.003349948

Score:  0.267

Data Source:  BioPlex,STRINGDB

SLC25A51

Tbio

Family:  Transporter

Novelty:  0.21568087

p_int:  0.995138178

p_ni:  0.00477183

p_wrong:  0.000089991

Score:  0.177

Data Source:  BioPlex,STRINGDB

TSPO

Tchem

Novelty:  0.00082324

p_int:  0.991838937

p_ni:  0.004544996

p_wrong:  0.003616068

Score:  0.208

Data Source:  BioPlex,STRINGDB

PIGW

Tbio

Novelty:  0.0245774

p_int:  0.988383021

p_ni:  0.001028956

p_wrong:  0.010588023

Data Source:  BioPlex

SLC19A2

Tbio

Family:  Transporter

Novelty:  0.00761796

p_int:  0.981651685

p_ni:  0.018278717

p_wrong:  0.000069598

Score:  0.269

Data Source:  BioPlex,STRINGDB

Publication Statistics

PubMed Score  74.57

PubMed score by year

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PubTator Score  21.85

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Cytoplasm
Glycoprotein
Membrane
Reference proteome
Sugar transport
Transmembrane
Transmembrane helix
Transport

GWAS Trait Find Similar Targets

No Header	No Header
blood urea nitrogen measurement
C-reactive protein measurement
Calcium channel blocker use measurement
coronary artery disease
creatinine measurement
Diuretic use measurement
forced expiratory volume
glomerular filtration rate
hemoglobin measurement

MGI Phenotype Find Similar Targets

No Header	No Header
digestive/alimentary phenotype