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Tbio
SLC2A12
Solute carrier family 2, facilitated glucose transporter member 12

Protein Summary
Description
Facilitative glucose transporter. SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275230
  • ENSP00000275230
  • ENSG00000146411

Symbol
  • GLUT12
  • GLUT8
  • GLUT8
  • GLUT12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.74
gene perturbation
0.68
protein domain
0.58
microRNA
0.54
transcription factor perturbation
0.54


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.57   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.57   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
2
3
1.1
92.4
hemoglobin measurement
2
2
2
62.6
creatinine measurement
1
1
1
58.4
glomerular filtration rate
1
1
1
57.3
Diuretic use measurement
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
92.4
hemoglobin measurement
2
62.6
creatinine measurement
1
58.4
glomerular filtration rate
1
57.3
Diuretic use measurement
1
47.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 2 member 12
VGNC:7925
472131
Macaque
solute carrier family 2 member 12
707255
Mouse
MGI:3052471
353169
Rat
RGD:1310175
308028
Dog
solute carrier family 2 member 12
VGNC:46339
483994
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 2 member 12
Macaque
solute carrier family 2 member 12
Mouse
Rat
Dog
solute carrier family 2 member 12
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TD20-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Cellular hexose transport (R-HSA-189200)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular hexose transport
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Cellular hexose transport
SLC-mediated transmembrane transport
Transport of small molecules
Protein-Protein Interactions (105)
1 – 10 of 105
TMEM242
Tdark
Novelty:  0.99055845
p_int:  0.999933724
p_ni:  0.000064468
p_wrong:  0.000001808
Score:  0.179
Data Source:  BioPlex,STRINGDB
TAMM41
Tbio
Family:  Enzyme
Novelty:  0.06004824
p_int:  0.999459163
p_ni:  0.000540837
p_wrong:  1e-9
Score:  0.245
Data Source:  BioPlex,STRINGDB
MTFR2
Tbio
Novelty:  0.20272025
p_int:  0.999424357
p_ni:  0.000394648
p_wrong:  0.000180995
Data Source:  BioPlex
ORMDL2
Tdark
Novelty:  0.37598406
p_int:  0.998772392
p_ni:  0.000794159
p_wrong:  0.000433448
Score:  0.156
Data Source:  BioPlex,STRINGDB
SLC25A23
Tbio
Family:  Transporter
Novelty:  0.10446757
p_int:  0.997800051
p_ni:  0.002192653
p_wrong:  0.000007296
Score:  0.288
Data Source:  BioPlex,STRINGDB
SLC25A28
Tbio
Family:  Transporter
Novelty:  0.05050869
p_int:  0.996523301
p_ni:  0.00012675
p_wrong:  0.003349948
Score:  0.267
Data Source:  BioPlex,STRINGDB
SLC25A51
Tbio
Family:  Transporter
Novelty:  0.21568087
p_int:  0.995138178
p_ni:  0.00477183
p_wrong:  0.000089991
Score:  0.177
Data Source:  BioPlex,STRINGDB
TSPO
Tchem
Novelty:  0.00082324
p_int:  0.991838937
p_ni:  0.004544996
p_wrong:  0.003616068
Score:  0.208
Data Source:  BioPlex,STRINGDB
PIGW
Tbio
Novelty:  0.0245774
p_int:  0.988383021
p_ni:  0.001028956
p_wrong:  0.010588023
Data Source:  BioPlex
SLC19A2
Tbio
Family:  Transporter
Novelty:  0.00761796
p_int:  0.981651685
p_ni:  0.018278717
p_wrong:  0.000069598
Score:  0.269
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  74.57

PubMed score by year
PubTator Score  21.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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