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Tchem
NEK9
Serine/threonine-protein kinase Nek9

Protein Summary
Description
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively. This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238616
  • ENSP00000238616
  • ENSG00000119638

Symbol
  • KIAA1995
  • NEK8
  • NERCC
  • NC
  • APUG
  • NERCC
  • LCCS10
  • NERCC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
virus perturbation
0.98
drug perturbation
0.96
molecular function
0.96
histone modification site profile
0.88


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.5   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 446   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.5   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 446   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL475251
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
2
34.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
34.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NIMA related kinase 9
VGNC:7449
467512
Macaque
NIMA related kinase 9
701707
Mouse
MGI:2387995
217718
Rat
RGD:1307187
299204
Dog
NIMA related kinase 9
VGNC:43735
490790
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NIMA related kinase 9
Macaque
NIMA related kinase 9
Mouse
Rat
Dog
NIMA related kinase 9
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8TD19-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Activation of NIMA Kinases NEK9, NEK6, NEK7 (R-HSA-2980767)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NIMA Kinases NEK9, NEK6, NEK7
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
M Phase
Reactome
Mitotic Prophase
Name
Explore in Pharos
Explore in Source
Activation of NIMA Kinases NEK9, NEK6, NEK7
Cell Cycle
Cell Cycle, Mitotic
M Phase
Mitotic Prophase
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (103)
1 – 10 of 103
NEK6
Tchem
Family: Kinase
Novelty: 0.02394134
p_int: 0.982898868
p_ni: 0.017101132
Score: 0.986
Data Source: BioPlex,Reactome,STRINGDB
MAFF
Tbio
Family: TF
Novelty: 0.01974936
p_int: 0.866894065
p_ni: 0.133105932
p_wrong: 3e-9
Score: 0.234
Data Source: BioPlex,STRINGDB
RNF19B
Tbio
Family: Enzyme
Novelty: 0.20054824
p_int: 0.857389633
p_ni: 0.142610367
Score: 0.202
Data Source: BioPlex,STRINGDB
ITIH5
Tbio
Novelty: 0.07069373
p_int: 0.760441637
p_ni: 0.239558363
Data Source: BioPlex
NEK7
Tchem
Family: Kinase
Novelty: 0.02675561
Score: 0.997
Data Source: STRINGDB
PLK1
Tchem
Family: Kinase
Novelty: 0.00062799
Score: 0.96
Data Source: Reactome,STRINGDB
BICD2
Tbio
Novelty: 0.01725046
Score: 0.946
Data Source: STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.925
Data Source: Reactome,STRINGDB
NUP93
Tbio
Novelty: 0.0248311
Score: 0.924
Data Source: STRINGDB
CCNB1
Tchem
Novelty: 0.0005503
Score: 0.92
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  46.50

PubMed score by year
PubTator Score  15.15

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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