NEK9
Serine/threonine-protein kinase Nek9
Protein Summary
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively. This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016]
- ENST00000238616
- ENSP00000238616
- ENSG00000119638
- KIAA1995
- NEK8
- NERCC
- NC
- APUG
- NERCC
- LCCS10
- NERCC1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
virus perturbation | 0.98 | ||
drug perturbation | 0.96 | ||
molecular function | 0.96 | ||
histone modification site profile | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 49.82 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 446 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 49.82 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 446 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (103)
NEK6
Family: Kinase
Novelty: 0.02394134
p_int: 0.982898868
p_ni: 0.017101132
Score: 0.986
Data Source: BioPlex,Reactome,STRINGDB
MAFF
Family: TF
Novelty: 0.01974936
p_int: 0.866894065
p_ni: 0.133105932
p_wrong: 3e-9
Score: 0.234
Data Source: BioPlex,STRINGDB
RNF19B
Family: Enzyme
Novelty: 0.20054824
p_int: 0.857389633
p_ni: 0.142610367
Score: 0.202
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (7)
Reactome (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of NIMA Kinases NEK9, NEK6, NEK7 | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | M Phase | ||||
Reactome | Mitotic Prophase | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of NIMA Kinases NEK9, NEK6, NEK7 | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
M Phase | ||||
Mitotic Prophase | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (4)
Components (2)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 3 | 3 | 86.6 | |||||
placenta growth factor measurement | 1 | 1 | 1 | 82.9 | |||||
5 | 4 | 4 | 1 | 72.1 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 86.6 | |||||
placenta growth factor measurement | 1 | 82.9 | |||||
4 | 1 | 72.1 | |||||
Find similar targets by:
IDG Resources
Data Resources (2)
NanoBRET
- Institute: UNC-CH
- Authors: Julie Pickett
- PI: Tim Willson
- Assay ID: BAO_0010069
- Endpoint: fold change
- Endpoint Detection: fluorescence intensity
- Repository: Synapse
NanoBRET
- Institute: UNC-CH
- Authors: Julie Pickett
- PI: Tim Willson
- Assay ID: BAO_0010069
- Endpoint: fold change
- Endpoint Detection: fluorescence intensity
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | NIMA related kinase 9 | VGNC:7449 | 467512 | |||||
Macaque | NIMA related kinase 9 | 701707 | ||||||
Mouse | MGI:2387995 | 217718 | ||||||
Rat | RGD:1307187 | 299204 | ||||||
Dog | NIMA related kinase 9 | VGNC:43735 | 490790 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | NIMA related kinase 9 | |||||
Macaque | NIMA related kinase 9 | |||||
Mouse | ||||||
Rat | ||||||
Dog | NIMA related kinase 9 | |||||
Publication Statistics
PubMed Score 49.82
PubMed score by year
PubTator Score 15.15
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (37)
GeneRif Annotations (20)
Items per page:
0 of 0
PMID | Year | Title |
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