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Tbio
BICD2
Protein bicaudal D homolog 2

Protein Summary
Description
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosome ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356884
  • ENSP00000349351
  • ENSG00000185963
  • ENST00000375512
  • ENSP00000364662

Symbol
  • KIAA0699
  • SMALED2
  • SMALED2A
  • SMALED2B
  • bA526D8.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.95
microRNA
0.9
transcription factor binding site profile
0.87
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.62   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.62   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
BICD1
Tbio
Novelty:  0.02109123
p_int:  1
Score:  0.903
Data Source:  BioPlex,STRINGDB
PMF1
Tbio
Novelty:  0.05319446
p_int:  0.99999989
p_ni:  1.1e-7
Data Source:  BioPlex
UNC5CL
Tbio
Novelty:  0.11511991
p_int:  0.999980346
p_ni:  0.000019654
Score:  0.213
Data Source:  BioPlex,STRINGDB
MIS18A
Tbio
Novelty:  0.08143008
p_int:  0.999976379
p_ni:  0.000023621
Data Source:  BioPlex
NEFL
Tbio
Novelty:  0.00049255
p_int:  0.999885206
p_ni:  0.000114794
Score:  0.324
Data Source:  BioPlex,STRINGDB
BORCS6
Tdark
Novelty:  0.83789033
p_int:  0.99987303
p_ni:  0.00012697
Data Source:  BioPlex
RGPD8
Tdark
Novelty:  0.12397737
p_int:  0.999747597
p_ni:  0.000252403
Score:  0.155
Data Source:  BioPlex,STRINGDB
TCP10L
Tbio
Novelty:  0.24089479
p_int:  0.999504178
p_ni:  0.000495715
p_wrong:  1.07e-7
Data Source:  BioPlex
ORC6
Tbio
Novelty:  0.02529139
p_int:  0.999401281
p_ni:  0.000598585
p_wrong:  1.35e-7
Score:  0.211
Data Source:  BioPlex,STRINGDB
VPS41
Tbio
Novelty:  0.08480171
p_int:  0.999253245
p_ni:  0.000134374
p_wrong:  0.000612381
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
COPI-independent Golgi-to-ER retrograde traffic (R-HSA-6811436)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
Golgi-to-ER retrograde transport
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
COPI-independent Golgi-to-ER retrograde traffic
Golgi-to-ER retrograde transport
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
4
4
89.9
body height
3
3
3
88.1
waist-hip ratio
3
4
4
69.6
myeloid white cell count
1
1
1
59
BMI-adjusted hip circumference
1
3
3
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
4
89.9
body height
3
88.1
waist-hip ratio
4
69.6
myeloid white cell count
1
59
BMI-adjusted hip circumference
3
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BICD cargo adaptor 2
VGNC:9214
465233
Macaque
BICD cargo adaptor 2
706621
Mouse
MGI:1924145
76895
Rat
RGD:735093
306809
Dog
BICD cargo adaptor 2
VGNC:38451
484214
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BICD cargo adaptor 2
Macaque
BICD cargo adaptor 2
Mouse
Rat
Dog
BICD cargo adaptor 2
Publication Statistics
PubMed Score 67.62
PubMed score by year
PubTator Score 32.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title