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Tchem
MAPK15
Mitogen-activated protein kinase 15

Protein Summary
Description
Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:22948227, PubMed:24618899, PubMed:29021280, PubMed:21847093, PubMed:20733054). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338033
  • ENSP00000337691
  • ENSG00000181085
  • ENST00000395107
  • ENSP00000378539
  • ENST00000395108
  • ENSP00000378540
  • ENST00000615253
  • ENSP00000483093
  • ENSG00000274205

Symbol
  • ERK7
  • ERK8
  • ERK7
  • ERK8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
small molecule
0.95
cell type or tissue
0.93
pathway
0.87
biological process
0.74


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2652894
332110
Rat
RGD:628675
286997
Dog
mitogen-activated protein kinase 15
VGNC:42996
482080
Cow
mitogen-activated protein kinase 15
VGNC:31217
512125
Opossum
mitogen-activated protein kinase 15
100016623
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
mitogen-activated protein kinase 15
Cow
mitogen-activated protein kinase 15
Opossum
mitogen-activated protein kinase 15
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TD08-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (35)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (68)
1 – 10 of 68
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
p_int: 0.988276162
p_ni: 0.0000999
p_wrong: 0.011623938
Score: 0.408
Data Source: BioPlex,STRINGDB
NAMPT
Tchem
Family: Enzyme
Novelty: 0.00093316
p_int: 0.899314463
p_ni: 0.100685537
Score: 0.329
Data Source: BioPlex,STRINGDB
CCT2
Tbio
Novelty: 0.01967139
p_int: 0.873663155
p_ni: 0.126336845
Score: 0.246
Data Source: BioPlex,STRINGDB
CCT3
Tbio
Novelty: 0.01642521
p_int: 0.85515433
p_ni: 0.14484567
Score: 0.418
Data Source: BioPlex,STRINGDB
CCT6B
Tdark
Novelty: 0.28933315
p_int: 0.774172531
p_ni: 0.225827469
Score: 0.315
Data Source: BioPlex,STRINGDB
CLIC3
Tbio
Family: IC
Novelty: 0.07268934
Score: 0.939
Data Source: STRINGDB
CLIC2
Tbio
Family: IC
Novelty: 0.03695725
Score: 0.8
Data Source: STRINGDB
CLIC1
Tbio
Family: IC
Novelty: 0.00622691
Score: 0.716
Data Source: STRINGDB
MBP
Tbio
Novelty: 0.00016333
Score: 0.683
Data Source: STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
Score: 0.671
Data Source: STRINGDB
Publication Statistics
PubMed Score  48.00

PubMed score by year
PubTator Score  23.13

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer