Tchem MAPK15 Mitogen-activated protein kinase 15

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Mitogen-activated Protein Kinase 15

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Mapk Family / Erk7 Subfamily / Mitogen-activated Protein Kinase 15

Protein Summary

Description

Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:22948227, PubMed:24618899, PubMed:29021280, PubMed:21847093, PubMed:20733054). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:20638370, PubMed:19166846). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936).

Uniprot Accession IDs

• Q8TD08
• Q2TCF9
• Q8N362
• MAP kinase 15

Gene Name

• MAPK15

Ensembl ID

• ENST00000338033
• ENSP00000337691
• ENSG00000181085
• ENST00000395107
• ENSP00000378539
• ENST00000395108
• ENSP00000378540
• ENST00000615253
• ENSP00000483093
• ENSG00000274205

Symbol

• ERK7
• ERK8
• ERK7
• ERK8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
small molecule	0.95
cell type or tissue	0.93
pathway	0.87
biological process	0.74

Related Tools

Dark Kinase Knowledgebase

The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.

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ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.46   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 321   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.46   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (4)

Explore Active Ligands

1 – 4 of 4

staurosporine

MAPK15Tchem Kinase

IC50 : 8.14

lestaurtinib

MAPK15Tchem Kinase

Kd : 8.31

R547

MAPK15Tchem Kinase

Kd : 7.75

BS-194

MAPK15Tchem Kinase

IC50 : 6.48000002

GWAS Traits (8)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	ENSG00000181085	2	1	2		83.2
red blood cell distribution width	EFO_0005192	ENSG00000274205	2	1	2		83.2
age at menarche	EFO_0004703	ENSG00000181085	1	1	1		24.5
age at menarche	EFO_0004703	ENSG00000274205	1	1	1		24.5
appendicular lean mass	EFO_0004980	ENSG00000274205	1	1	1		21.5

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	2		83.2
red blood cell distribution width	EFO_0005192	2		83.2
age at menarche	EFO_0004703	1		24.5
age at menarche	EFO_0004703	1		24.5
appendicular lean mass	EFO_0004980	1		21.5

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Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	mitogen-activated protein kinase 15	MGI:2652894	332110
Rat	mitogen-activated protein kinase 15	RGD:628675	286997
Dog	mitogen-activated protein kinase 15	VGNC:42996	482080
Cow	mitogen-activated protein kinase 15	VGNC:31217	512125
Opossum	mitogen-activated protein kinase 15		100016623

Species	Name	OMA	EggNOG	Inparanoid
Mouse	mitogen-activated protein kinase 15
Rat	mitogen-activated protein kinase 15
Dog	mitogen-activated protein kinase 15
Cow	mitogen-activated protein kinase 15
Opossum	mitogen-activated protein kinase 15

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q8TD08-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (41)

KEGG (1)

PathwayCommons (5)

WikiPathways (35)

Find Similar Targets

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	IL-17 signaling pathway	92 targets	path:hsa04657

Name	Explore in Pharos	Explore in Source
IL-17 signaling pathway	92 targets	path:hsa04657

Gene Ontology Terms (35)

Functions (6)

Components (12)

Processes (17)

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Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
chromatin binding	Inferred from Direct Assay (IDA)	UniProtKB
kinase activity	Inferred from Direct Assay (IDA)	UniProtKB
MAP kinase activity	Inferred from Direct Assay (IDA)	UniProtKB
protein kinase activity	Inferred from Direct Assay (IDA)	UniProtKB
SH3 domain binding	Non-traceable Author Statement (NAS)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (68)

Explore Interacting Targets

1 – 10 of 68

• See Interactions on String-DB

CDK2

Tchem

Family:  Kinase

Novelty:  0.00032118

p_int:  0.988276162

p_ni:  0.0000999

p_wrong:  0.011623938

Score:  0.408

Data Source:  BioPlex,STRINGDB

NAMPT

Tchem

Family:  Enzyme

Novelty:  0.00093316

p_int:  0.899314463

p_ni:  0.100685537

Score:  0.329

Data Source:  BioPlex,STRINGDB

CCT2

Tbio

Novelty:  0.01967139

p_int:  0.873663155

p_ni:  0.126336845

Score:  0.246

Data Source:  BioPlex,STRINGDB

CCT3

Tbio

Novelty:  0.01642521

p_int:  0.85515433

p_ni:  0.14484567

Score:  0.418

Data Source:  BioPlex,STRINGDB

CCT6B

Tdark

Novelty:  0.28933315

p_int:  0.774172531

p_ni:  0.225827469

Score:  0.315

Data Source:  BioPlex,STRINGDB

CLIC3

Tbio

Family:  IC

Novelty:  0.07268934

Score:  0.939

Data Source:  STRINGDB

CLIC2

Tbio

Family:  IC

Novelty:  0.03695725

Score:  0.8

Data Source:  STRINGDB

CLIC1

Tbio

Family:  IC

Novelty:  0.00622691

Score:  0.716

Data Source:  STRINGDB

MBP

Tbio

Novelty:  0.00016333

Score:  0.683

Data Source:  STRINGDB

JUN

Tchem

Family:  TF

Novelty:  0.00006856

Score:  0.671

Data Source:  STRINGDB

Publication Statistics

PubMed Score  50.46

PubMed score by year

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PubTator Score  23.13

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Ortholog Sequence Conservation

WebLogo Color Code

PolarG S T Y C

NeutralQ N

BasicK R H

AcidicD E

HydrophobicA V L I P W F M

Compare across kinases on ProKinO

Structural Annotations

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
ATP-binding
Cell junction
Cell projection
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton
Golgi apparatus
Kinase

GWAS Trait Find Similar Targets

No Header	No Header
age at menarche
appendicular lean mass
diastolic blood pressure
red blood cell distribution width

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype