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Tbio
RAET1E
Retinoic acid early transcript 1E

Protein Summary
Description
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357183
  • ENSP00000349709
  • ENSG00000164520
  • ENST00000367363
  • ENSP00000356332
  • ENST00000529948
  • ENSP00000432366
  • ENST00000532335
  • ENSP00000437067

Symbol
  • LETAL
  • N2DL4
  • ULBP4
  • RL-4
  • LETAL
  • ULBP4
  • N2DL-4
  • NKG2DL4
  • RAET1E2
  • bA350J20.7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.76
tissue
0.46
cell line
0.44
disease
0.44
cellular component
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.82   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 318   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.82   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 318   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
NRN1
Tbio
Novelty:  0.01198116
p_int:  0.999918176
p_ni:  0.000081325
p_wrong:  5e-7
Data Source:  BioPlex
RYK
Tbio
Family:  Kinase
Novelty:  0.00910227
p_int:  0.999385976
p_ni:  0.000612018
p_wrong:  0.000002006
Score:  0.392
Data Source:  BioPlex,STRINGDB
ULBP2
Tbio
Novelty:  0.01604318
p_int:  0.998345178
p_ni:  0.001654817
p_wrong:  5e-9
Score:  0.279
Data Source:  BioPlex,STRINGDB
TNFSF9
Tbio
Novelty:  0.00532152
p_int:  0.99702501
p_ni:  0.00297499
Score:  0.167
Data Source:  BioPlex,STRINGDB
SDK2
Tdark
Novelty:  0.08867136
p_int:  0.995825013
p_ni:  0.003708595
p_wrong:  0.000466391
Score:  0.179
Data Source:  BioPlex,STRINGDB
ULBP3
Tbio
Novelty:  0.0320239
p_int:  0.994343666
p_ni:  0.005656327
p_wrong:  7e-9
Score:  0.229
Data Source:  BioPlex,STRINGDB
PODXL2
Tbio
Novelty:  0.09100487
p_int:  0.992337227
p_ni:  0.0075037
p_wrong:  0.000159073
Data Source:  BioPlex
RAB3B
Tbio
Family:  Enzyme
Novelty:  0.02731183
p_int:  0.990396532
p_ni:  0.007345015
p_wrong:  0.002258454
Data Source:  BioPlex
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
p_int:  0.98988822
p_ni:  0.010110816
p_wrong:  9.64e-7
Data Source:  BioPlex
IGDCC4
Tbio
Novelty:  0.13243246
p_int:  0.955031674
p_ni:  0.000006179
p_wrong:  0.044962148
Score:  0.199
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 52.82
PubMed score by year
PubTator Score 45.29
PubTator score by year
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Related Publications
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PMID
Year
Title