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Tbio
CD99L2
CD99 antigen-like protein 2

Protein Summary
Description
Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity). This gene encodes a cell-surface protein that is similar to CD99. A similar protein in mouse functions as an adhesion molecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346693
  • ENSP00000489222
  • ENSG00000102181
  • ENST00000355149
  • ENSP00000347275
  • ENST00000370377
  • ENSP00000359403
  • ENST00000437787
  • ENSP00000394858
  • ENST00000466436
  • ENSP00000417697
  • ENST00000613030
  • ENSP00000480322

Symbol
  • MIC2L1
  • CD99B
  • MIC2L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
disease perturbation
0.87
transcription factor perturbation
0.74
kinase perturbation
0.71
cellular component
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.27   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.27   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
CAPN1
Tchem
Novelty:  0.00252811
p_int:  0.999999995
p_wrong:  5e-9
Score:  0.277
Data Source:  BioPlex,STRINGDB
CD99
Tbio
Novelty:  0.00229439
Score:  0.911
Data Source:  Reactome,STRINGDB
IDH3G
Tbio
Family:  Enzyme
Novelty:  0.04861242
Score:  0.7
Data Source:  STRINGDB
VMA21
Tdark
Family:  Enzyme
Novelty:  0.46129032
Score:  0.659
Data Source:  STRINGDB
AIFM1
Tbio
Novelty:  0.00940088
Score:  0.591
Data Source:  STRINGDB
XG
Tdark
Novelty:  0.10977081
Score:  0.585
Data Source:  STRINGDB
NONO
Tbio
Novelty:  0.00501502
Score:  0.554
Data Source:  STRINGDB
ESAM
Tbio
Novelty:  0.00462452
Score:  0.551
Data Source:  STRINGDB
ADAP1
Tbio
Novelty:  0.03287486
Score:  0.546
Data Source:  STRINGDB
MTMR1
Tbio
Family:  Enzyme
Novelty:  0.06694505
Score:  0.538
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
56.6
HbA1c measurement
1
1
1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
56.6
HbA1c measurement
1
1.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD99 molecule like 2
VGNC:12241
465906
Macaque
CD99 molecule like 2
708996
Mouse
MGI:2177151
171486
Rat
RGD:11437172
108348081
Dog
CD99 molecule like 2
VGNC:54128
100685328
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD99 molecule like 2
Macaque
CD99 molecule like 2
Mouse
Rat
Dog
CD99 molecule like 2
Publication Statistics
PubMed Score 11.27
PubMed score by year
PubTator Score 3.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title