Tbio MRAP Melanocortin-2 receptor accessory protein

Protein Summary

Description

Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells. This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009]

Uniprot Accession IDs

• Q8TCY5
• Q5EBR3
• Q8TDB7
• Q8WXC1
• Q8WXC2

Gene Name

• MRAP

Ensembl ID

• ENST00000303645
• ENSP00000306697
• ENSG00000170262
• ENST00000339944
• ENSP00000343661
• ENST00000399784
• ENSP00000382684

Symbol

• C21orf61
• FALP
• B27
• FALP
• FGD2
• GCCD2
• C21orf61

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.75
cell type or tissue	0.67
disease	0.57
tissue	0.57
biological process	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.93   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.93   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0