Tbio RHPN1 Rhophilin-1

Protein Summary

Description

Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules.

Uniprot Accession IDs

• Q8TCX5
• Q8TAV1
• Q96PV9

Gene Name

• RHPN1

Ensembl ID

• ENST00000289013
• ENSP00000289013
• ENSG00000158106

Symbol

• KIAA1929
• ODF5
• RHPN
• RHOPHILIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.84
cell line	0.53
gene perturbation	0.52
metabolite	0.45
cell type or tissue	0.44

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Rhophilin-1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Rhophilin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.64   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.64   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (84)

Explore Interacting Targets

1 – 10 of 84

• See Interactions on String-DB

PTPN14

Tbio

Family:  Enzyme

Novelty:  0.01333024

p_int:  0.999999748

p_ni:  2.42e-7

p_wrong:  1e-8

Score:  0.169

Data Source:  BioPlex,STRINGDB

PTPN21

Tbio

Family:  Enzyme

Novelty:  0.07773004

p_int:  0.999988297

p_ni:  3.6e-8

p_wrong:  0.000011667

Score:  0.208

Data Source:  BioPlex,STRINGDB

WWC1

Tbio

Novelty:  0.00905646

p_int:  0.999983028

p_ni:  0.00001691

p_wrong:  6.2e-8

Score:  0.299

Data Source:  BioPlex,STRINGDB

WWC2

Tbio

Novelty:  0.13357975

p_int:  0.99997431

p_ni:  0.000019978

p_wrong:  0.000005712

Score:  0.319

Data Source:  BioPlex,STRINGDB

GOLGA2

Tbio

Novelty:  0.00544771

p_int:  0.999966856

p_ni:  0.000033144

Score:  0.159

Data Source:  BioPlex,STRINGDB

KLHL11

Tbio

Novelty:  0.1537041

p_int:  0.999966079

p_ni:  0.000033912

p_wrong:  9e-9

Data Source:  BioPlex

PODXL2

Tbio

Novelty:  0.09100487

p_int:  0.999914959

p_ni:  0.000083999

p_wrong:  0.000001042

Score:  0.22

Data Source:  BioPlex,STRINGDB

TTC19

Tbio

Novelty:  0.08251578

p_int:  0.999904633

p_ni:  0.000095366

p_wrong:  1e-9

Data Source:  BioPlex

PODXL

Tbio

Novelty:  0.00306913

p_int:  0.99985101

p_ni:  0.000148971

p_wrong:  1.9e-8

Data Source:  BioPlex

KIF2A

Tbio

Novelty:  0.01463006

p_int:  0.999829311

p_ni:  0.000170643

p_wrong:  4.6e-8

Score:  0.184

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (4)

WikiPathways (1)

RHO GTPase Effectors (R-HSA-195258)

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Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	RHO GTPase Effectors	273 targets	R-HSA-195258
Reactome	RHO GTPases Activate Rhotekin and Rhophilins	9 targets	R-HSA-5666185
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by Rho GTPases	402 targets	R-HSA-194315

Name	Explore in Pharos	Explore in Source
RHO GTPase Effectors	273 targets	R-HSA-195258
RHO GTPases Activate Rhotekin and Rhophilins	9 targets	R-HSA-5666185
Signal Transduction	2704 targets	R-HSA-162582
Signaling by Rho GTPases	402 targets	R-HSA-194315

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (2)

Components (1)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
cytosol	Traceable Author Statement (TAS)	Reactome

Disease Associations (null)

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1	1	1		64.9
BMI-adjusted hip circumference	EFO_0008039	1	2	2		40.4
body fat percentage	EFO_0007800	1	1	1		14.2
high density lipoprotein cholesterol measurement	EFO_0004612	1	1	1		10.1
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		9.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1		64.9
BMI-adjusted hip circumference	EFO_0008039	2		40.4
body fat percentage	EFO_0007800	1		14.2
high density lipoprotein cholesterol measurement	EFO_0004612	1		10.1
apolipoprotein A 1 measurement	EFO_0004614	1		9.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Coiled coil
Complete proteome
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
BMI-adjusted hip circumference
body fat percentage
body height
high density lipoprotein cholesterol measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
homeostasis/metabolism phenotype
nervous system phenotype
renal/urinary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	rhophilin Rho GTPase binding protein 1	VGNC:14577	464442
Macaque	rhophilin Rho GTPase binding protein 1		696895
Mouse	rhophilin, Rho GTPase binding protein 1	MGI:1098783	14787
Rat	rhophilin, Rho GTPase binding protein 1	RGD:1305688	300030
Dog	rhophilin Rho GTPase binding protein 1	VGNC:45567	482076

Species	Name	OMA	EggNOG	Inparanoid
Chimp	rhophilin Rho GTPase binding protein 1
Macaque	rhophilin Rho GTPase binding protein 1
Mouse	rhophilin, Rho GTPase binding protein 1
Rat	rhophilin, Rho GTPase binding protein 1
Dog	rhophilin Rho GTPase binding protein 1

Publication Statistics

PubMed Score 13.64

PubMed score by year

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PubTator Score 6.14

PubTator score by year

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Related Publications

Text Mined References (9)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title