Protein Summary
Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules.
- ENST00000289013
- ENSP00000289013
- ENSG00000158106
- KIAA1929
- ODF5
- RHPN
- RHOPHILIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.84 | ||
cell line | 0.53 | ||
gene perturbation | 0.52 | ||
metabolite | 0.45 | ||
cell type or tissue | 0.44 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.64 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 156 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.64 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 156 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (84)
PTPN14
Family: Enzyme
Novelty: 0.01333024
p_int: 0.999999748
p_ni: 2.42e-7
p_wrong: 1e-8
Score: 0.169
Data Source: BioPlex,STRINGDB
PTPN21
Family: Enzyme
Novelty: 0.07773004
p_int: 0.999988297
p_ni: 3.6e-8
p_wrong: 0.000011667
Score: 0.208
Data Source: BioPlex,STRINGDB
WWC1
Novelty: 0.00905646
p_int: 0.999983028
p_ni: 0.00001691
p_wrong: 6.2e-8
Score: 0.299
Data Source: BioPlex,STRINGDB
WWC2
Novelty: 0.13357975
p_int: 0.99997431
p_ni: 0.000019978
p_wrong: 0.000005712
Score: 0.319
Data Source: BioPlex,STRINGDB
GOLGA2
Novelty: 0.00544771
p_int: 0.999966856
p_ni: 0.000033144
Score: 0.159
Data Source: BioPlex,STRINGDB
KLHL11
Novelty: 0.1537041
p_int: 0.999966079
p_ni: 0.000033912
p_wrong: 9e-9
Data Source: BioPlex
PODXL2
Novelty: 0.09100487
p_int: 0.999914959
p_ni: 0.000083999
p_wrong: 0.000001042
Score: 0.22
Data Source: BioPlex,STRINGDB
TTC19
Novelty: 0.08251578
p_int: 0.999904633
p_ni: 0.000095366
p_wrong: 1e-9
Data Source: BioPlex
PODXL
Novelty: 0.00306913
p_int: 0.99985101
p_ni: 0.000148971
p_wrong: 1.9e-8
Data Source: BioPlex
KIF2A
Novelty: 0.01463006
p_int: 0.999829311
p_ni: 0.000170643
p_wrong: 4.6e-8
Score: 0.184
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (4)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | RHO GTPase Effectors | ||||
Reactome | RHO GTPases Activate Rhotekin and Rhophilins | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Rho GTPases | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
RHO GTPase Effectors | ||||
RHO GTPases Activate Rhotekin and Rhophilins | ||||
Signal Transduction | ||||
Signaling by Rho GTPases | ||||
Viral Interactions (0)
Gene Ontology Terms (2)
Components (1)
Processes (1)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body height | 1 | 1 | 1 | 64.9 | |||||
BMI-adjusted hip circumference | 1 | 2 | 2 | 40.4 | |||||
body fat percentage | 1 | 1 | 1 | 14.2 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 10.1 | |||||
apolipoprotein A 1 measurement | 1 | 1 | 1 | 9.2 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body height | 1 | 64.9 | |||||
BMI-adjusted hip circumference | 2 | 40.4 | |||||
body fat percentage | 1 | 14.2 | |||||
high density lipoprotein cholesterol measurement | 1 | 10.1 | |||||
apolipoprotein A 1 measurement | 1 | 9.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | rhophilin Rho GTPase binding protein 1 | VGNC:14577 | 464442 | |||||
Macaque | rhophilin Rho GTPase binding protein 1 | 696895 | ||||||
Mouse | MGI:1098783 | 14787 | ||||||
Rat | RGD:1305688 | 300030 | ||||||
Dog | rhophilin Rho GTPase binding protein 1 | VGNC:45567 | 482076 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | rhophilin Rho GTPase binding protein 1 | |||||
Macaque | rhophilin Rho GTPase binding protein 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | rhophilin Rho GTPase binding protein 1 | |||||
Publication Statistics
PubMed Score 13.64
PubMed score by year
PubTator Score 6.14
PubTator score by year
Related Publications
Text Mined References (9)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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