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Tclin
GRIN3A
Glutamate receptor ionotropic, NMDA 3A

Protein Summary
Description
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity). This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361820
  • ENSP00000355155
  • ENSG00000198785

Symbol
  • KIAA1973
  • NR3A
  • GluN3A
  • NMDAR-L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
drug
0.94
microRNA
0.66
cell line
0.6
gene perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.35   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.35   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Pathways (24)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
Gene Ontology Terms (22)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (108)
1 – 10 of 108
GRIN1
Tclin
Family: IC
Novelty: 0.00132693
Score: 0.971
Data Source: Reactome,STRINGDB
DLG4
Tchem
Novelty: 0.00079421
Score: 0.965
Data Source: STRINGDB
GRIN2B
Tclin
Family: IC
Novelty: 0.00042857
Score: 0.95
Data Source: Reactome,STRINGDB
GRIN2A
Tclin
Family: IC
Novelty: 0.00075253
Score: 0.949
Data Source: Reactome,STRINGDB
GRIN2C
Tclin
Family: IC
Novelty: 0.00588631
Score: 0.934
Data Source: STRINGDB
GRIN2D
Tclin
Family: IC
Novelty: 0.00730668
Score: 0.931
Data Source: STRINGDB
GRIA1
Tclin
Family: IC
Novelty: 0.00063312
Score: 0.831
Data Source: STRINGDB
CACNG2
Tbio
Family: IC
Novelty: 0.01171137
Score: 0.824
Data Source: STRINGDB
GRIA2
Tclin
Family: IC
Novelty: 0.00187801
Score: 0.821
Data Source: STRINGDB
GRIA4
Tclin
Family: IC
Novelty: 0.00363124
Score: 0.821
Data Source: STRINGDB
Publication Statistics
PubMed Score  81.35

PubMed score by year
PubTator Score  47.95

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer