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Tbio
ALMS1
Alstrom syndrome protein 1

Protein Summary
Description
Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells. This gene encodes a protein containing a large tandem-repeat domain as well as additional low complexity regions. The encoded protein functions in microtubule organization, particularly in the formation and maintanance of cilia. Mutations in this gene cause Alstrom syndrome. There is a pseudogene for this gene located adjacent in the same region of chromosome 2. Alternative splice variants have been described but their full length nature has not been determined. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000613296
  • ENSP00000482968
  • ENSG00000116127

Symbol
  • KIAA0328
  • ALSS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.74
virus perturbation
0.72
phenotype
0.69
histone modification site profile
0.68
disease
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.37   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.37   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (217)
FBLIM1
Tbio
Novelty:  0.0332985
p_int:  0.999818952
p_ni:  0.000181048
Data Source:  BioPlex
AARSD1
Tdark
Novelty:  0.75372406
p_int:  0.999086838
p_ni:  0.000913162
Data Source:  BioPlex
C6orf141
Tdark
Novelty:  1.46022784
p_int:  0.998432394
p_ni:  0.001567488
p_wrong:  1.19e-7
Data Source:  BioPlex
PRELID2
Tdark
Novelty:  0.38276284
p_int:  0.998084015
p_ni:  0.001915985
Data Source:  BioPlex
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.997553142
p_ni:  0.002446858
Data Source:  BioPlex
BBS7
Tbio
Novelty:  0.03611111
p_int:  0.997002324
p_ni:  0.002997676
Score:  0.608
Data Source:  BioPlex,STRINGDB
THSD4
Tbio
Novelty:  0.12898073
p_int:  0.99301258
p_ni:  0.00698742
Data Source:  BioPlex
DRC3
Tdark
Novelty:  0.99283468
p_int:  0.988809815
p_ni:  0.011190185
Data Source:  BioPlex
NCAPH2
Tbio
Novelty:  0.12134933
p_int:  0.981492988
p_ni:  0.018506998
p_wrong:  1.4e-8
Data Source:  BioPlex
TFDP3
Tbio
Family:  TF
Novelty:  0.00223003
p_int:  0.9536692
p_ni:  0.0463308
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
AURKA Activation by TPX2 (R-HSA-8854518)

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Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
14
13
22
94.7
99.9
serum metabolite measurement
15
11
19
1
99.8
urinary metabolite measurement
4
11
16
99.8
metabolite measurement
4
4
3
1.1
99.5
glomerular filtration rate
11
10
11
10.3
99.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
22
94.7
99.9
serum metabolite measurement
19
1
99.8
urinary metabolite measurement
16
99.8
metabolite measurement
3
1.1
99.5
glomerular filtration rate
11
10.3
99.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ALMS1, centrosome and basal body associated protein
VGNC:10521
459324
Macaque
ALMS1, centrosome and basal body associated protein
706612
Mouse
MGI:1934606
236266
Rat
RGD:1311590
297408
Dog
ALMS1, centrosome and basal body associated protein
475795
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ALMS1, centrosome and basal body associated protein
Macaque
ALMS1, centrosome and basal body associated protein
Mouse
Rat
Dog
ALMS1, centrosome and basal body associated protein
Publication Statistics
PubMed Score 201.37
PubMed score by year
PubTator Score 85.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title