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Tbio
HM13
Minor histocompatibility antigen H13

Protein Summary
Description
Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity). The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335574
  • ENSP00000335294
  • ENSG00000101294
  • ENST00000340852
  • ENSP00000343032
  • ENST00000398174
  • ENSP00000381237

Symbol
  • H13
  • IMP1
  • PSL3
  • SPP
  • H13
  • SPP
  • IMP1
  • PSL3
  • IMPAS
  • SPPL1
  • PSENL3
  • IMPAS-1
  • MSTP086
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
transcription factor binding site profile
0.95
cellular component
0.84
kinase perturbation
0.84
interacting protein
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.35   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.35   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
66.6
apolipoprotein A 1 measurement
1
1
1
27.5
eosinophil count
1
1
1
13.1
high density lipoprotein cholesterol measurement
1
1
1
9.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
66.6
apolipoprotein A 1 measurement
1
27.5
eosinophil count
1
13.1
high density lipoprotein cholesterol measurement
1
9.4
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histocompatibility minor 13
107966374
Macaque
histocompatibility minor 13
713216
Mouse
MGI:95886
14950
Rat
RGD:1308946
311545
Dog
histocompatibility minor 13
VGNC:41702
608355
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histocompatibility minor 13
Macaque
histocompatibility minor 13
Mouse
Rat
Dog
histocompatibility minor 13
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TCT9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (80)
1 – 10 of 80
CCR6
Tchem
Family: GPCR
Novelty: 0.00257933
p_int: 0.9125973
p_ni: 0.0874027
Data Source: BioPlex
TMEM266
Tdark
Novelty: 0.26313861
p_int: 0.882619123
p_ni: 0.117380877
Score: 0.359
Data Source: BioPlex,STRINGDB
RNF139
Tbio
Family: Enzyme
Novelty: 0.05828557
Score: 0.936
Data Source: STRINGDB
SSR2
Tbio
Novelty: 0.01383689
Score: 0.924
Data Source: STRINGDB
TRAM1
Tbio
Novelty: 0.17795822
Score: 0.918
Data Source: STRINGDB
DERL1
Tbio
Novelty: 0.01382722
Score: 0.896
Data Source: STRINGDB
SEC11C
Tdark
Family: Enzyme
Novelty: 0.19577003
Score: 0.862
Data Source: STRINGDB
SSR3
Tbio
Novelty: 0.05838475
Score: 0.857
Data Source: STRINGDB
HSP90B1
Tchem
Novelty: 0.00135881
Score: 0.839
Data Source: STRINGDB
LMAN1
Tbio
Novelty: 0.00595367
Score: 0.829
Data Source: STRINGDB
Publication Statistics
PubMed Score  168.35

PubMed score by year
PubTator Score  1029.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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