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Tchem
SPPL2A
Signal peptide peptidase-like 2A

Protein Summary
Description
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). This gene encodes a member of the GXGD family of aspartic protease ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261854
  • ENSP00000261854
  • ENSG00000138600

Symbol
  • IMP3
  • PSL2
  • IMP3
  • PSL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
transcription factor binding site profile
0.82
histone modification site profile
0.79
small molecule perturbation
0.75
cellular component
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.42   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.42   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (10)
1 – 10 of 10
CHEMBL392068
Rendered image for CHEMBL392068
CHEMBL4069936
Rendered image for CHEMBL4069936
CHEMBL4059711
Rendered image for CHEMBL4059711
CHEMBL255473
Rendered image for CHEMBL255473
CHEMBL4077007
Rendered image for CHEMBL4077007
CHEMBL4076827
Rendered image for CHEMBL4076827
CHEMBL4064631
Rendered image for CHEMBL4064631
CHEMBL4100749
Rendered image for CHEMBL4100749
CHEMBL4077336
Rendered image for CHEMBL4077336
CHEMBL4074838
Rendered image for CHEMBL4074838
Protein-Protein Interactions (27)
1 – 10 of 27
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.953780722
p_ni:  0.000001015
p_wrong:  0.046218263
Score:  0.189
Data Source:  BioPlex,STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.918
Data Source:  STRINGDB
ITM2B
Tbio
Novelty:  0.00977027
Score:  0.662
Data Source:  STRINGDB
ANKMY2
Tdark
Novelty:  0.50777631
Score:  0.661
Data Source:  STRINGDB
NMT1
Tchem
Family:  Enzyme
Novelty:  0.00343834
Score:  0.646
Data Source:  STRINGDB
TSPAN13
Tbio
Novelty:  0.12118479
Score:  0.623
Data Source:  STRINGDB
AP4E1
Tdark
Novelty:  0.09773225
Score:  0.602
Data Source:  STRINGDB
LMAN2L
Tbio
Novelty:  0.04364985
Score:  0.6
Data Source:  STRINGDB
HEXB
Tchem
Family:  Enzyme
Novelty:  0.0085045
Score:  0.596
Data Source:  STRINGDB
CD74
Tchem
Novelty:  0.00281228
Score:  0.581
Data Source:  STRINGDB
Pathways (4)
Death Receptor Signalling (R-HSA-73887)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Death Receptor Signalling
Reactome
Regulation of TNFR1 signaling
Reactome
Signal Transduction
Reactome
TNF signaling
Name
Explore in Pharos
Explore in Source
Death Receptor Signalling
Regulation of TNFR1 signaling
Signal Transduction
TNF signaling
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
3
90
myeloid white cell count
1
1
1
82
leukocyte count
1
1
1
76.8
fibrinogen measurement
4
4
4
72.8
lymphocyte count
2
2
2
66.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
90
myeloid white cell count
1
82
leukocyte count
1
76.8
fibrinogen measurement
4
72.8
lymphocyte count
2
66.5
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal peptide peptidase like 2A
VGNC:1872
453430
Mouse
MGI:1913802
66552
Rat
RGD:1563001
311401
Dog
signal peptide peptidase like 2A
VGNC:46758
478301
Horse
signal peptide peptidase like 2A
VGNC:23535
100069832
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal peptide peptidase like 2A
Mouse
Rat
Dog
signal peptide peptidase like 2A
Horse
signal peptide peptidase like 2A
Publication Statistics
PubMed Score 39.42
PubMed score by year
PubTator Score 20.63
PubTator score by year