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Tbio
SPPL2B
Signal peptide peptidase-like 2B

Protein Classes
Protein Summary
Description
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610743
  • ENSP00000478510
  • ENSG00000005206
  • ENST00000613503
  • ENSP00000478298
  • ENST00000618220
  • ENSP00000480813

Symbol
  • IMP4
  • KIAA1532
  • PSL1
  • IMP4
  • PSH4
  • PSL1
  • IMP-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.85
histone modification site profile
0.76
tissue
0.67
kinase perturbation
0.66
transcription factor binding site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.42   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.42   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Death Receptor Signalling (R-HSA-73887)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Death Receptor Signalling
Reactome
Regulation of TNFR1 signaling
Reactome
Signal Transduction
Reactome
TNF signaling
Name
Explore in Pharos
Explore in Source
Death Receptor Signalling
Regulation of TNFR1 signaling
Signal Transduction
TNF signaling
Protein-Protein Interactions (121)
1 – 10 of 121
SLC30A5
Tbio
Family: Transporter
Novelty: 0.03895139
p_int: 0.999995648
p_ni: 0.000004352
Data Source: BioPlex
PIGN
Tbio
Family: Enzyme
Novelty: 0.00990325
p_int: 0.999963416
p_ni: 0.000036429
p_wrong: 1.54e-7
Data Source: BioPlex
KTN1
Tbio
Novelty: 0.011349
p_int: 0.999947902
p_ni: 0.000052098
Data Source: BioPlex
SLC30A6
Tbio
Family: Transporter
Novelty: 0.09437965
p_int: 0.999940761
p_ni: 0.000059202
p_wrong: 3.6e-8
Data Source: BioPlex
SLC35G2
Tdark
Family: Transporter
Novelty: 1.2962963
p_int: 0.999915549
p_ni: 0.000075975
p_wrong: 0.000008475
Data Source: BioPlex
IGSF3
Tbio
Novelty: 0.02583319
p_int: 0.999914058
p_ni: 0.000085941
p_wrong: 1e-9
Data Source: BioPlex
P2RX4
Tchem
Family: IC
Novelty: 0.00292374
p_int: 0.999903309
p_ni: 0.000096569
p_wrong: 1.22e-7
Data Source: BioPlex
TMEM8A
Tdark
Novelty: 0.22292994
p_int: 0.999838688
p_ni: 0.000075478
p_wrong: 0.000085834
Data Source: BioPlex
PIGW
Tbio
Novelty: 0.04018898
p_int: 0.999771188
p_ni: 0.000228812
Data Source: BioPlex
MTCH1
Tbio
Novelty: 0.16333938
p_int: 0.999714193
p_ni: 0.000285807
Score: 0.315
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  26.42

PubMed score by year
PubTator Score  18.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer