Tbio SPPL3 Signal peptide peptidase-like 3

Protein Summary

Description

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971).

Uniprot Accession IDs

• Q8TCT6
• Q3MJ04
• Q8TAU4
• Q96DD9
• SPP-like 3

Gene Name

• SPPL3

Ensembl ID

• ENST00000353487
• ENSP00000288680
• ENSG00000157837

Symbol

• IMP2
• PSL4
• IMP2
• PSH1
• PSL4
• PRO4332
• MDHV1887

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
kinase perturbation	0.95
disease perturbation	0.87
microRNA	0.83
transcription factor binding site profile	0.76

Protein Classes

PANTHER Classes

Protein / ... / Aspartic Protease / Signal Peptide Peptidase-like 3

DTO Classes

Protein / Enzyme / Protease / Aspartic Protease / Signal Peptide Peptidase-like 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.38   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 104   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.38   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0