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Tchem
PHOSPHO1
Phosphoethanolamine/phosphocholine phosphatase

Protein Classes
Protein Summary
Description
Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310544
  • ENSP00000311925
  • ENSG00000173868
  • ENST00000413580
  • ENSP00000406909
  • ENST00000514112
  • ENSP00000427694
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
transcription factor
0.67
phenotype
0.65
tissue sample
0.62
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.09   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.09   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
lansoprazole
Rendered image for lansoprazole
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
95.8
testosterone measurement
2
2
2
92.7
refractive error measurement
2
3
2
6.3
88.2
eosinophil count
2
1
2
83.1
triglyceride measurement
2
2
2
81.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
95.8
testosterone measurement
2
92.7
refractive error measurement
2
6.3
88.2
eosinophil count
2
83.1
triglyceride measurement
2
81.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphoethanolamine/phosphocholine phosphatase
VGNC:9519
455200
Macaque
phosphoethanolamine/phosphocholine phosphatase
698959
Mouse
MGI:2447348
237928
Rat
RGD:1306182
287644
Dog
phosphoethanolamine/phosphocholine phosphatase
VGNC:49702
491069
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphoethanolamine/phosphocholine phosphatase
Macaque
phosphoethanolamine/phosphocholine phosphatase
Mouse
Rat
Dog
phosphoethanolamine/phosphocholine phosphatase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TCT1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PC
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PC
Protein-Protein Interactions (52)
1 – 10 of 52
CHTF18
Tbio
Novelty:  0.02470494
p_int:  0.986067349
p_ni:  0.013901349
p_wrong:  0.000031302
Score:  0.513
Data Source:  BioPlex,STRINGDB
ACY1
Tbio
Family:  Enzyme
Novelty:  0.00912344
p_int:  0.907177698
p_ni:  0.092822302
Score:  0.418
Data Source:  BioPlex,STRINGDB
PCYT1A
Tchem
Family:  Enzyme
Novelty:  0.00621528
Score:  0.924
Data Source:  STRINGDB
GPCPD1
Tdark
Family:  Enzyme
Novelty:  0.03548168
Score:  0.908
Data Source:  STRINGDB
PCYT1B
Tbio
Family:  Enzyme
Novelty:  0.02972878
Score:  0.904
Data Source:  STRINGDB
PCYT2
Tbio
Family:  Enzyme
Novelty:  0.03267621
Score:  0.901
Data Source:  STRINGDB
ETNPPL
Tbio
Family:  Enzyme
Novelty:  0.11207676
Score:  0.9
Data Source:  STRINGDB
ACHE
Tclin
Family:  Enzyme
Novelty:  0.00026957
Score:  0.9
Data Source:  STRINGDB
CHAT
Tchem
Family:  Enzyme
Novelty:  0.00033026
Score:  0.9
Data Source:  STRINGDB
CHKB
Tbio
Family:  Kinase
Novelty:  0.00862294
Score:  0.843
Data Source:  STRINGDB
Publication Statistics
PubMed Score  16.09

PubMed score by year
PubTator Score  15.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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