Protein Classes
Protein Summary
Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides. CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]
- ENST00000216264
- ENSP00000216264
- ENSG00000100422
- KIAA1646
- LK4
- hCERK
- dA59H18.2
- dA59H18.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.98 | ||
molecular function | 0.96 | ||
virus perturbation | 0.95 | ||
transcription factor perturbation | 0.91 | ||
transcription factor binding site profile | 0.74 | ||
Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 108.6 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 293 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 108.6 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 293 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (1)
1 – 1 of 1
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ceramide kinase | VGNC:5975 | 458921 | |||||
Macaque | ceramide kinase | 714480 | ||||||
Mouse | MGI:2386052 | 223753 | ||||||
Rat | RGD:1305019 | 300129 | ||||||
Dog | ceramide kinase | VGNC:54519 | 474464 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ceramide kinase | |||||
Macaque | ceramide kinase | |||||
Mouse | ||||||
Rat | ||||||
Dog | ceramide kinase | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (62)
Reactome (4)
KEGG (1)
WikiPathways (57)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Glycosphingolipid metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Sphingolipid metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Glycosphingolipid metabolism | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Sphingolipid metabolism | ||||
Gene Ontology Terms (10)
Functions (5)
Components (3)
Processes (2)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (90)
1 – 10 of 90
PDCD2
Novelty: 0.05054811
p_int: 0.999973464
p_ni: 0.000026524
p_wrong: 1.2e-8
Data Source: BioPlex
GMNN
Novelty: 0.00436572
p_int: 0.999607641
p_ni: 0.00039235
p_wrong: 9e-9
Data Source: BioPlex
KCTD17
Novelty: 0.12105733
p_int: 0.999491937
p_ni: 0.000508063
Score: 0.153
Data Source: BioPlex,STRINGDB
CCNDBP1
Novelty: 0.01527762
p_int: 0.999392091
p_ni: 0.000605688
p_wrong: 0.000002221
Score: 0.177
Data Source: BioPlex,STRINGDB
TNFRSF9
Novelty: 0.00162382
p_int: 0.996073064
p_ni: 0.003814281
p_wrong: 0.000112655
Score: 0.261
Data Source: BioPlex,STRINGDB
VWCE
Novelty: 0.09328341
p_int: 0.993913181
p_ni: 0.005564123
p_wrong: 0.000522696
Data Source: BioPlex
HEPACAM2
Novelty: 0.19192547
p_int: 0.992706426
p_ni: 0.006073343
p_wrong: 0.001220231
Data Source: BioPlex
HAVCR2
Novelty: 0.00155885
p_int: 0.989670341
p_ni: 0.010307763
p_wrong: 0.000021896
Data Source: BioPlex
CD83
Novelty: 0.00138653
p_int: 0.975386702
p_ni: 0.023241376
p_wrong: 0.001371922
Data Source: BioPlex
TPCN2
Family: IC
Novelty: 0.01351129
p_int: 0.969441356
p_ni: 0.026782971
p_wrong: 0.003775674
Data Source: BioPlex
Publication Statistics
PubMed Score 108.60
PubMed score by year
PubTator Score 46.41
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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