Tchem CERK Ceramide kinase

Protein Summary

Description

Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides. CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8TCT0
• A0JNT4
• A8K611
• Q6NX59
• Q9BYB3
• Q9UGE5
• hCERK

Gene Name

• CERK

Ensembl ID

• ENST00000216264
• ENSP00000216264
• ENSG00000100422

Symbol

• KIAA1646
• LK4
• hCERK
• dA59H18.2
• dA59H18.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
molecular function	0.96
virus perturbation	0.95
transcription factor perturbation	0.91
transcription factor binding site profile	0.74

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.78   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 293   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.78   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

NVP 231

CERKTchem Kinase

-: 7.9

Pathways (62)

Reactome (4)

KEGG (1)

WikiPathways (57)

Glycosphingolipid metabolism (R-HSA-1660662)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Glycosphingolipid metabolism	46 targets	R-HSA-1660662
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Sphingolipid metabolism	90 targets	R-HSA-428157

Name	Explore in Pharos	Explore in Source
Glycosphingolipid metabolism	46 targets	R-HSA-1660662
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Sphingolipid metabolism	90 targets	R-HSA-428157

Gene Ontology Terms (10)

Functions (5)

Components (3)

Processes (2)

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
ceramide kinase activity	Inferred from Direct Assay (IDA)	UniProtKB
magnesium ion binding	Inferred from Direct Assay (IDA)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
dihydroceramide kinase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
NAD+ kinase activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (90)

Explore Interacting Targets

1 – 10 of 90

• See Interactions on String-DB

PDCD2

Tbio

Novelty: 0.05415706

p_int: 0.999973464

p_ni: 0.000026524

p_wrong: 1.2e-8

Data Source: BioPlex

GMNN

Tbio

Novelty: 0.00563598

p_int: 0.999607641

p_ni: 0.00039235

p_wrong: 9e-9

Data Source: BioPlex

KCTD17

Tbio

Novelty: 0.20322581

p_int: 0.999491937

p_ni: 0.000508063

Score: 0.153

Data Source: BioPlex,STRINGDB

CCNDBP1

Tbio

Novelty: 0.02585442

p_int: 0.999392091

p_ni: 0.000605688

p_wrong: 0.000002221

Score: 0.177

Data Source: BioPlex,STRINGDB

TNFRSF9

Tbio

Novelty: 0.00148448

p_int: 0.996073064

p_ni: 0.003814281

p_wrong: 0.000112655

Score: 0.261

Data Source: BioPlex,STRINGDB

VWCE

Tbio

Novelty: 0.10129635

p_int: 0.993913181

p_ni: 0.005564123

p_wrong: 0.000522696

Data Source: BioPlex

HEPACAM2

Tbio

Novelty: 0.13703845

p_int: 0.992706426

p_ni: 0.006073343

p_wrong: 0.001220231

Data Source: BioPlex

HAVCR2

Tbio

Novelty: 0.00217571

p_int: 0.989670341

p_ni: 0.010307763

p_wrong: 0.000021896

Data Source: BioPlex

CD83

Tbio

Novelty: 0.00171116

p_int: 0.975386702

p_ni: 0.023241376

p_wrong: 0.001371922

Data Source: BioPlex

TPCN2

Tchem

Family: IC

Novelty: 0.01836974

p_int: 0.969441356

p_ni: 0.026782971

p_wrong: 0.003775674

Data Source: BioPlex

Publication Statistics

PubMed Score  87.78

PubMed score by year

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PubTator Score  46.41

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Sequence

MGATGAAEPLQSVLWVKQQRCAVSLEPARALLRWWRSPGPGAGAPGADACSVPVSEIIAVEETDVHGKHQ

1-70

GSGKWQKMEKPYAFTVHCVKRARRHRWKWAQVTFWCPEEQLCHLWLQTLREMLEKLTSRPKHLLVFINPF

70-140

GGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETLYEINIDKYDGIVCVGGDGMFSEVLHGLIGR

140-210

TQRSAGVDQNHPRAVLVPSSLRIGIIPAGSTDCVCYSTVGTSDAETSALHIVVGDSLAMDVSSVHHNSTL

210-280

LRYSVSLLGYGFYGDIIKDSEKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKPCRAG

280-350

CFVCRQSKQQLEEEQKKALYGLEAAEDVEEWQVVCGKFLAINATNMSCACRRSPRGLSPAAHLGDGSSDL

350-420

ILIRKCSRFNFLRFLIRHTNQQDQFDFTFVEVYRVKKFQFTSKHMEDEDSDLKEGGKKRFGHICSSHPSC

420-490

CCTVSNSSWNCDGEVLHSPAIEVRVHCQLVRLFARGIEENPKPDSHS

490-537

MGATGAAEPLQSVLWVKQQRCAVSLEPARALLRWWRSPGPGAGAPGADACSVPVSEIIAVEETDVHGKHQGSGKWQKMEKPYAFTVHCVKRARRHRWKWAQVTFWCPEEQLCHLWLQTLREMLEKLTSRPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETLYEINIDKYDGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGSTDCVCYSTVGTSDAETSALHIVVGDSLAMDVSSVHHNSTLLRYSVSLLGYGFYGDIIKDSEKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKPCRAGCFVCRQSKQQLEEEQKKALYGLEAAEDVEEWQVVCGKFLAINATNMSCACRRSPRGLSPAAHLGDGSSDLILIRKCSRFNFLRFLIRHTNQQDQFDFTFVEVYRVKKFQFTSKHMEDEDSDLKEGGKKRFGHICSSHPSCCCTVSNSSWNCDGEVLHSPAIEVRVHCQLVRLFARGIEENPKPDSHS

Find similar targets by:

Uniprot Keyword

Alternative splicing
ATP-binding
Calcium
Complete proteome
Cytoplasm
Kinase
Magnesium
Membrane
Nucleotide-binding
Phosphoprotein