Protein Summary
Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides. CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]
- ENST00000216264
- ENSP00000216264
- ENSG00000100422
- KIAA1646
- LK4
- hCERK
- dA59H18.2
- dA59H18.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.98 | ||
molecular function | 0.96 | ||
virus perturbation | 0.95 | ||
transcription factor perturbation | 0.91 | ||
transcription factor binding site profile | 0.74 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 87.78 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 293 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 87.78 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 293 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (1)
1 – 1 of 1
Pathways (62)
Reactome (4)
KEGG (1)
WikiPathways (57)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Glycosphingolipid metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Sphingolipid metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Glycosphingolipid metabolism | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Sphingolipid metabolism | ||||
Gene Ontology Terms (10)
Functions (5)
Components (3)
Processes (2)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (90)
1 – 10 of 90
PDCD2
Novelty: 0.05415706
p_int: 0.999973464
p_ni: 0.000026524
p_wrong: 1.2e-8
Data Source: BioPlex
GMNN
Novelty: 0.00563598
p_int: 0.999607641
p_ni: 0.00039235
p_wrong: 9e-9
Data Source: BioPlex
KCTD17
Novelty: 0.20322581
p_int: 0.999491937
p_ni: 0.000508063
Score: 0.153
Data Source: BioPlex,STRINGDB
CCNDBP1
Novelty: 0.02585442
p_int: 0.999392091
p_ni: 0.000605688
p_wrong: 0.000002221
Score: 0.177
Data Source: BioPlex,STRINGDB
TNFRSF9
Novelty: 0.00148448
p_int: 0.996073064
p_ni: 0.003814281
p_wrong: 0.000112655
Score: 0.261
Data Source: BioPlex,STRINGDB
VWCE
Novelty: 0.10129635
p_int: 0.993913181
p_ni: 0.005564123
p_wrong: 0.000522696
Data Source: BioPlex
HEPACAM2
Novelty: 0.13703845
p_int: 0.992706426
p_ni: 0.006073343
p_wrong: 0.001220231
Data Source: BioPlex
HAVCR2
Novelty: 0.00217571
p_int: 0.989670341
p_ni: 0.010307763
p_wrong: 0.000021896
Data Source: BioPlex
CD83
Novelty: 0.00171116
p_int: 0.975386702
p_ni: 0.023241376
p_wrong: 0.001371922
Data Source: BioPlex
TPCN2
Family: IC
Novelty: 0.01836974
p_int: 0.969441356
p_ni: 0.026782971
p_wrong: 0.003775674
Data Source: BioPlex
Publication Statistics
PubMed Score 87.78
PubMed score by year
PubTator Score 46.41
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Sequence
MGATGAAEPLQSVLWVKQQRCAVSLEPARALLRWWRSPGPGAGAPGADACSVPVSEIIAVEETDVHGKHQ
1-70
GSGKWQKMEKPYAFTVHCVKRARRHRWKWAQVTFWCPEEQLCHLWLQTLREMLEKLTSRPKHLLVFINPF
70-140
GGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETLYEINIDKYDGIVCVGGDGMFSEVLHGLIGR
140-210
TQRSAGVDQNHPRAVLVPSSLRIGIIPAGSTDCVCYSTVGTSDAETSALHIVVGDSLAMDVSSVHHNSTL
210-280
LRYSVSLLGYGFYGDIIKDSEKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKPCRAG
280-350
CFVCRQSKQQLEEEQKKALYGLEAAEDVEEWQVVCGKFLAINATNMSCACRRSPRGLSPAAHLGDGSSDL
350-420
ILIRKCSRFNFLRFLIRHTNQQDQFDFTFVEVYRVKKFQFTSKHMEDEDSDLKEGGKKRFGHICSSHPSC
420-490
CCTVSNSSWNCDGEVLHSPAIEVRVHCQLVRLFARGIEENPKPDSHS
490-537
MGATGAAEPLQSVLWVKQQRCAVSLEPARALLRWWRSPGPGAGAPGADACSVPVSEIIAVEETDVHGKHQGSGKWQKMEKPYAFTVHCVKRARRHRWKWAQVTFWCPEEQLCHLWLQTLREMLEKLTSRPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETLYEINIDKYDGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGSTDCVCYSTVGTSDAETSALHIVVGDSLAMDVSSVHHNSTLLRYSVSLLGYGFYGDIIKDSEKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKPCRAGCFVCRQSKQQLEEEQKKALYGLEAAEDVEEWQVVCGKFLAINATNMSCACRRSPRGLSPAAHLGDGSSDLILIRKCSRFNFLRFLIRHTNQQDQFDFTFVEVYRVKKFQFTSKHMEDEDSDLKEGGKKRFGHICSSHPSCCCTVSNSSWNCDGEVLHSPAIEVRVHCQLVRLFARGIEENPKPDSHS
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