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Tbio
PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial

Protein Summary
Description
RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-my ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000415374
  • ENSP00000393953
  • ENSG00000138035
  • ENST00000447944
  • ENSP00000400646

Symbol
  • PNPASE
  • OLD35
  • DFNB70
  • PNPASE
  • old-35
  • COXPD13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
virus perturbation
1
biological process
0.93
molecular function
0.91
disease perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 294.08   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 293   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 294.08   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (246)
1 – 10 of 246
TCL1A
Tbio
Novelty:  0.00606987
p_int:  0.999993315
p_ni:  0.000006685
Score:  0.292
Data Source:  BioPlex,STRINGDB
TBRG4
Tbio
Novelty:  0.03556613
p_int:  0.999277968
p_ni:  0.000722032
Score:  0.629
Data Source:  BioPlex,STRINGDB
FAHD1
Tbio
Family:  Enzyme
Novelty:  0.07873941
p_int:  0.999064509
p_ni:  0.000935491
Score:  0.325
Data Source:  BioPlex,STRINGDB
SERPINA12
Tbio
Novelty:  0.00549132
p_int:  0.995434104
p_ni:  0.004565896
Score:  0.185
Data Source:  BioPlex,STRINGDB
TMED2
Tbio
Novelty:  0.03731104
p_int:  0.994173575
p_ni:  0.005826425
Score:  0.202
Data Source:  BioPlex,STRINGDB
SUPV3L1
Tbio
Family:  Enzyme
Novelty:  0.01598799
p_int:  0.988759077
p_ni:  0.007531329
p_wrong:  0.003709595
Score:  0.994
Data Source:  BioPlex,STRINGDB
LRFN2
Tbio
Novelty:  0.07450569
p_int:  0.978060725
p_ni:  0.02193927
p_wrong:  5e-9
Data Source:  BioPlex
ACAD9
Tbio
Family:  Enzyme
Novelty:  0.03238308
p_int:  0.935159536
p_ni:  0.064840464
Score:  0.205
Data Source:  BioPlex,STRINGDB
ATP5F1D
Tbio
Family:  Enzyme
Novelty:  0.07296539
p_int:  0.932449144
p_ni:  0.067550856
Score:  0.27
Data Source:  BioPlex,STRINGDB
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.823143839
p_ni:  0.176856161
Score:  0.357
Data Source:  BioPlex,STRINGDB
Gene Ontology Terms (41)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
10
14
90
BMI-adjusted waist circumference
2
6
6
77.4
1
1
0
1.5
71.3
diastolic blood pressure
1
1
1
33.1
autoimmune thyroid disease
1
1
0
1.1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
14
90
BMI-adjusted waist circumference
6
77.4
0
1.5
71.3
diastolic blood pressure
1
33.1
autoimmune thyroid disease
0
1.1
30.2
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polyribonucleotide nucleotidyltransferase 1
VGNC:337
459247
Macaque
polyribonucleotide nucleotidyltransferase 1
718973
Mouse
MGI:1918951
71701
Rat
RGD:1307987
360992
Dog
polyribonucleotide nucleotidyltransferase 1
VGNC:44760
481376
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polyribonucleotide nucleotidyltransferase 1
Macaque
polyribonucleotide nucleotidyltransferase 1
Mouse
Rat
Dog
polyribonucleotide nucleotidyltransferase 1
Publication Statistics
PubMed Score 294.08
PubMed score by year
PubTator Score 103.29
PubTator score by year