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Tbio
MARCH1
E3 ubiquitin-protein ligase MARCH1

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274056
  • ENSP00000274056
  • ENSG00000145416
  • ENST00000339875
  • ENSP00000345676
  • ENST00000503008
  • ENSP00000427223

Symbol
  • RNF171
  • RNF171
  • MARCH-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
microRNA
0.7
tissue sample
0.65
phenotype
0.58
cellular component
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.9   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.9   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
33.3
84.4
1
1
0
100
71
heart rate
1
12
0
5.3
55.6
response to beta blocker
1
12
0
5.3
55.6
Ischemic stroke
1
1
0
14.3
33
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
33.3
84.4
0
100
71
heart rate
0
5.3
55.6
response to beta blocker
0
5.3
55.6
Ischemic stroke
0
14.3
33
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
membrane associated ring-CH-type finger 1
VGNC:48917
461585
Mouse
MGI:1920175
72925
Rat
RGD:1305148
361135
Dog
membrane associated ring-CH-type finger 1
VGNC:43014
612618
Horse
membrane associated ring-CH-type finger 1
VGNC:19973
100061618
Species
Name
OMA
EggNOG
Inparanoid
Chimp
membrane associated ring-CH-type finger 1
Mouse
Rat
Dog
membrane associated ring-CH-type finger 1
Horse
membrane associated ring-CH-type finger 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TCQ1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Protein-Protein Interactions (66)
1 – 10 of 66
HLA-DRB1
Tchem
Novelty: 0.00240724
Score: 0.91
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.91
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.91
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.91
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.91
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.91
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.91
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.91
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.91
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.91
Data Source: STRINGDB
Publication Statistics
PubMed Score  46.90

PubMed score by year
PubTator Score  1467.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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