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Tbio
CPT1C
Carnitine O-palmitoyltransferase 1, brain isoform

Protein Summary
Description
May play a role in lipid metabolic process. This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein regulates the beta-oxidation and transport of long-chain fatty acids into mitochondria, and may play a role in the regulation of feeding behavior and whole-body energy homeostasis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323446
  • ENSP00000319343
  • ENSG00000169169
  • ENST00000392518
  • ENSP00000376303
  • ENST00000405931
  • ENSP00000384465
  • ENST00000598293
  • ENSP00000473028

Symbol
  • CATL1
  • CATL1
  • CPT1P
  • CPTIC
  • SPG73
  • CPT1-B
  • CPTI-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.81
histone modification site profile
0.69
tissue
0.61
virus perturbation
0.59
tissue sample
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.19   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.19   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (91)
1 – 10 of 91
CPT2
Tchem
Family:  Enzyme
Novelty:  0.00345645
Score:  0.933
Data Source:  STRINGDB
CRAT
Tbio
Family:  Enzyme
Novelty:  0.01242609
Score:  0.919
Data Source:  STRINGDB
ACACB
Tchem
Family:  Enzyme
Novelty:  0.00462116
Score:  0.901
Data Source:  STRINGDB
CHKB
Tbio
Family:  Kinase
Novelty:  0.00862294
Score:  0.817
Data Source:  STRINGDB
CPT1B
Tchem
Family:  Enzyme
Novelty:  0.00733077
Score:  0.809
Data Source:  STRINGDB
CPT1A
Tchem
Family:  Enzyme
Novelty:  0.00281783
Score:  0.809
Data Source:  STRINGDB
ACSL1
Tbio
Family:  Enzyme
Novelty:  0.00336161
Score:  0.794
Data Source:  STRINGDB
ACSL3
Tbio
Family:  Enzyme
Novelty:  0.01772336
Score:  0.785
Data Source:  STRINGDB
ACSL5
Tchem
Family:  Enzyme
Novelty:  0.00850919
Score:  0.77
Data Source:  STRINGDB
KLF5
Tchem
Family:  TF
Novelty:  0.00384971
Score:  0.747
Data Source:  STRINGDB
Pathways (13)
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Adipocytokine signaling pathway
KEGG
AMPK signaling pathway
KEGG
Thermogenesis
KEGG
Glucagon signaling pathway
KEGG
Fatty acid metabolism
Name
Explore in Pharos
Explore in Source
Adipocytokine signaling pathway
AMPK signaling pathway
Thermogenesis
Glucagon signaling pathway
Fatty acid metabolism
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
5
5
96.6
serum albumin measurement
1
4
4
92.1
urate measurement
2
2
4
71.8
mathematical ability
2
3
3
64.3
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
5
96.6
serum albumin measurement
4
92.1
urate measurement
4
71.8
mathematical ability
3
64.3
1
49.5
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carnitine palmitoyltransferase 1C
VGNC:10974
748258
Mouse
MGI:2446526
78070
Rat
RGD:1305384
308579
Dog
carnitine palmitoyltransferase 1C
VGNC:39581
100856778
Horse
carnitine palmitoyltransferase 1C
VGNC:16841
100056027
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carnitine palmitoyltransferase 1C
Mouse
Rat
Dog
carnitine palmitoyltransferase 1C
Horse
carnitine palmitoyltransferase 1C
Publication Statistics
PubMed Score 106.19
PubMed score by year
PubTator Score 22.18
PubTator score by year