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Tbio
PI4K2B
Phosphatidylinositol 4-kinase type 2-beta

Protein Classes
Protein Summary
Description
Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with other protein family members. This protein is involved in early T cell activation. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264864
  • ENSP00000264864
  • ENSG00000038210

Symbol
  • PIK42B
  • PI4KIIB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
transcription factor perturbation
0.8
gene perturbation
0.76
kinase perturbation
0.76
microRNA
0.62


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.04   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.04   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol 4-kinase type 2 beta
471160
Mouse
MGI:1914323
67073
Rat
RGD:1359515
305419
Dog
phosphatidylinositol 4-kinase type 2 beta
100682913
Horse
phosphatidylinositol 4-kinase type 2 beta
100067523
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol 4-kinase type 2 beta
Mouse
Rat
Dog
phosphatidylinositol 4-kinase type 2 beta
Horse
phosphatidylinositol 4-kinase type 2 beta
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8TCG2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the ER membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the ER membrane
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (99)
1 – 10 of 99
HAVCR2
Tbio
Novelty: 0.00155885
p_int: 0.998700473
p_ni: 0.001299527
Data Source: BioPlex
GMPPB
Tbio
Family: Enzyme
Novelty: 0.05106206
p_int: 0.993972612
p_ni: 0.006027388
Score: 0.224
Data Source: BioPlex,STRINGDB
GFOD1
Tdark
Family: Enzyme
Novelty: 0.35031766
p_int: 0.991967656
p_ni: 0.008032344
Data Source: BioPlex
LRRC61
Tdark
Novelty: 1.45343096
p_int: 0.986655492
p_ni: 0.013344508
Data Source: BioPlex
EFNB2
Tbio
Novelty: 0.00255095
p_int: 0.973724776
p_ni: 0.026275224
Data Source: BioPlex
MANSC1
Tdark
Novelty: 0.91681036
p_int: 0.940509162
p_ni: 0.059490838
Data Source: BioPlex
TRIP13
Tbio
Family: Enzyme
Novelty: 0.00660506
p_int: 0.939542766
p_ni: 0.060457234
Score: 0.181
Data Source: BioPlex,STRINGDB
SSSCA1
Tdark
Novelty: 0.53523038
p_int: 0.934697382
p_ni: 0.065302618
Data Source: BioPlex
FCER1A
Tbio
Novelty: 0.00362182
p_int: 0.927206159
p_ni: 0.072416459
p_wrong: 0.000377382
Data Source: BioPlex
SIRT6
Tchem
Family: Epigenetic
Novelty: 0.00155366
p_int: 0.88756836
p_ni: 0.112431639
p_wrong: 2e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  4.04

PubMed score by year
PubTator Score  9.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer