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Tdark
PHOSPHO2
Pyridoxal phosphate phosphatase PHOSPHO2

Protein Summary
Description
Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359744
  • ENSP00000352782
  • ENSG00000144362
  • ENST00000616481
  • ENSP00000481680
  • ENST00000616524
  • ENSP00000481046
  • ENST00000617738
  • ENSP00000481857
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor binding site profile
0.69
transcription factor perturbation
0.68
transcription factor
0.59
protein domain
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.25   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.25   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (17)
DNTTIP1
Tbio
Family:  Enzyme
Novelty:  0.1659073
p_int:  0.999632274
p_ni:  0.000070165
p_wrong:  0.000297561
Score:  0.379
Data Source:  BioPlex,STRINGDB
SIGLEC5
Tbio
Novelty:  0.02616618
p_int:  0.998491407
p_ni:  0.001487957
p_wrong:  0.000020636
Score:  0.309
Data Source:  BioPlex,STRINGDB
CPNE4
Tbio
Novelty:  0.08077992
p_int:  0.867543354
p_ni:  0.048642809
p_wrong:  0.083813837
Score:  0.194
Data Source:  BioPlex,STRINGDB
PNPO
Tchem
Family:  Enzyme
Novelty:  0.00919993
Score:  0.952
Data Source:  STRINGDB
PDXK
Tbio
Family:  Kinase
Novelty:  0.00976418
Score:  0.902
Data Source:  STRINGDB
AOX1
Tchem
Family:  Enzyme
Novelty:  0.0025823
Score:  0.9
Data Source:  STRINGDB
PDXP
Tbio
Family:  Enzyme
Novelty:  0.01015805
Score:  0.802
Data Source:  STRINGDB
PGD
Tchem
Family:  Enzyme
Novelty:  0.00576529
Score:  0.668
Data Source:  STRINGDB
C18orf32
Tdark
Novelty:  2.9164938
Score:  0.56
Data Source:  STRINGDB
OSTN
Tbio
Novelty:  0.03600367
Score:  0.547
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
46.1
monocyte count
1
1
1
44.2
platelet count
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
46.1
monocyte count
1
44.2
platelet count
1
31.4
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatase, orphan 2
VGNC:2753
459719
Mouse
MGI:1920623
73373
Rat
RGD:1359274
295663
Dog
phosphatase, orphan 2
VGNC:44506
100684043
Cow
phosphatase, orphan 2
VGNC:32843
507308
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatase, orphan 2
Mouse
Rat
Dog
phosphatase, orphan 2
Cow
phosphatase, orphan 2
Publication Statistics
PubMed Score 2.25
PubMed score by year
PubTator Score 4.33
PubTator score by year
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Related Publications
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PMID
Year
Title