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Tdark
MRPL30
39S ribosomal protein L30, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p and 12p. Read-through transcription also exists between this gene and the neighboring upstream lipoyltransferase 1 (LIPT1) gene. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338148
  • ENSP00000338057
  • ENSG00000185414
  • ENST00000409841
  • ENSP00000386752

Symbol
  • MRPL28
  • RPML28
  • L28MT
  • L30MT
  • MRPL28
  • RPML28
  • MRP-L28
  • MRP-L30
  • MRPL28M
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
kinase perturbation
0.81
transcription factor binding site profile
0.8
transcription factor perturbation
0.8
small molecule perturbation
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.03   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.03   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
MRPL51
Tdark
Novelty:  0.24304433
p_int:  0.999949933
p_ni:  0.000049934
p_wrong:  1.33e-7
Score:  0.982
Data Source:  BioPlex,STRINGDB
MRPL40
Tbio
Novelty:  0.09916967
p_int:  0.999888276
p_ni:  0.000111724
Score:  0.987
Data Source:  BioPlex,STRINGDB
MRPL55
Tdark
Novelty:  0.55956177
p_int:  0.999849424
p_ni:  0.000150576
Score:  0.954
Data Source:  BioPlex,STRINGDB
MRPL2
Tdark
Novelty:  1.01237797
p_int:  0.999803968
p_ni:  0.000196032
Score:  0.99
Data Source:  BioPlex,STRINGDB
MRPL58
Tbio
Family:  Enzyme
Novelty:  0.00178011
p_int:  0.99975142
p_ni:  0.00024858
Score:  0.982
Data Source:  BioPlex,STRINGDB
MRPS30
Tbio
Novelty:  0.08115544
p_int:  0.999747283
p_ni:  0.000252715
p_wrong:  2e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
MRPL47
Tbio
Novelty:  0.05648009
p_int:  0.999663456
p_ni:  0.000150369
p_wrong:  0.000186174
Score:  0.995
Data Source:  BioPlex,STRINGDB
MRPL20
Tdark
Novelty:  0.91178993
p_int:  0.99964171
p_ni:  0.00035829
Score:  0.986
Data Source:  BioPlex,STRINGDB
MTERF3
Tdark
Novelty:  0.06316581
p_int:  0.999632161
p_ni:  0.000367839
Data Source:  BioPlex
MRPL27
Tdark
Novelty:  0.15636105
p_int:  0.999607799
p_ni:  0.000392201
Score:  0.988
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
2
3
81.6
reticulocyte count
2
2
3
80
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
81.6
reticulocyte count
3
80
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 1.03
PubMed score by year
PubTator Score 0.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title