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Tbio
SUN5
SUN domain-containing protein 5

Protein Summary
Description
Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope. The protein encoded by this gene appears to play a role in the meiotic stage of spermatogenesis. The encoded protein localizes to the junction between the sperm head and body and may be involved in nuclear envelope reconstitution and nuclear migration. Mutations in this gene have been implicated in acephalic spermatozoa syndrome. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356173
  • ENSP00000348496
  • ENSG00000167098

Symbol
  • SPAG4L
  • TSARG4
  • SPAG4L
  • SPGF16
  • TSARG4
  • dJ726C3.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.65
cellular component
0.54
phenotype
0.44
tissue
0.43
disease
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.2   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.2   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (43)
1 – 10 of 43
DPY19L2
Tbio
Family: Enzyme
Novelty: 0.03435247
Score: 0.763
Data Source: STRINGDB
CCDC155
Tbio
Novelty: 0.16516035
Score: 0.665
Data Source: STRINGDB
ODF1
Tbio
Novelty: 0.01272872
Score: 0.64
Data Source: STRINGDB
SYNE3
Tbio
Novelty: 0.06515065
Score: 0.617
Data Source: STRINGDB
RFT1
Tbio
Novelty: 6.81081081
Score: 0.585
Data Source: STRINGDB
RTF1
Tbio
Family: Enzyme
Novelty: 0.02255644
Score: 0.585
Data Source: STRINGDB
BPIFA3
Tdark
Novelty: 2.57247859
Score: 0.585
Data Source: STRINGDB
BPIFB6
Tdark
Novelty: 0.66851502
Score: 0.581
Data Source: STRINGDB
GPATCH4
Tdark
Novelty: 1.13040547
Score: 0.571
Data Source: STRINGDB
SYNE4
Tbio
Novelty: 0.0739848
Score: 0.566
Data Source: STRINGDB
Publication Statistics
PubMed Score  22.20

PubMed score by year
PubTator Score  10.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer