You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
ENKUR
Enkurin

Protein Summary
Description
Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel. This gene encodes a protein that interacts with calmodulin and several transient receptor potential canonical cation channel proteins. The encoded protein may function as an adaptor to localize signal transduction machinery to calcium channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331161
  • ENSP00000331044
  • ENSG00000151023
  • ENST00000496261
  • ENSP00000432930

Symbol
  • C10orf63
  • CFAP106
  • C10orf63
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
tissue sample
0.69
microRNA
0.59
histone modification site profile
0.54
tissue
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.93   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.93   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
CFAP45
Tbio
Novelty:  0.12173319
Score:  0.864
Data Source:  STRINGDB
TRPC5
Tchem
Family:  IC
Novelty:  0.00406517
Score:  0.754
Data Source:  STRINGDB
CCDC113
Tdark
Novelty:  1.10748096
Score:  0.712
Data Source:  STRINGDB
TRPC1
Tbio
Family:  IC
Novelty:  0.00233677
Score:  0.711
Data Source:  STRINGDB
CFAP52
Tbio
Novelty:  0.23267809
Score:  0.653
Data Source:  STRINGDB
IQUB
Tdark
Novelty:  0.11732563
Score:  0.64
Data Source:  STRINGDB
FAM81B
Tdark
Novelty:  2.38747104
Score:  0.636
Data Source:  STRINGDB
LRRIQ1
Tdark
Novelty:  1.8251367
Score:  0.634
Data Source:  STRINGDB
PTPDC1
Tdark
Family:  Enzyme
Novelty:  0.38792241
Score:  0.626
Data Source:  STRINGDB
CFAP70
Tdark
Novelty:  1.0349863
Score:  0.616
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
3
9
98.2
neutrophil count
3
3
3
97.2
reticulocyte measurement
3
2
5
96.2
myeloid white cell count
2
2
2
95.6
monocyte count
2
2
2
95.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
9
98.2
neutrophil count
3
97.2
reticulocyte measurement
5
96.2
myeloid white cell count
2
95.6
monocyte count
2
95.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
enkurin, TRPC channel interacting protein
VGNC:9708
466270
Mouse
MGI:1918483
71233
Rat
RGD:1309839
291354
Dog
enkurin, TRPC channel interacting protein
VGNC:40365
487104
Horse
enkurin, TRPC channel interacting protein
VGNC:17582
100055627
Species
Name
OMA
EggNOG
Inparanoid
Chimp
enkurin, TRPC channel interacting protein
Mouse
Rat
Dog
enkurin, TRPC channel interacting protein
Horse
enkurin, TRPC channel interacting protein
Publication Statistics
PubMed Score 4.93
PubMed score by year
PubTator Score 2.70
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title