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Tbio
RDH11
Retinol dehydrogenase 11

Protein Summary
Description
Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. The protein encoded by this gene is an NADPH-dependent retinal reductase and a short-chain dehydrogenase/reductase. The encoded protein has no steroid dehydrogenase activity. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381346
  • ENSP00000370750
  • ENSG00000072042
  • ENST00000428130
  • ENSP00000416395
  • ENST00000553384
  • ENSP00000452079

Symbol
  • ARSDR1
  • PSDR1
  • SDR7C1
  • MDT1
  • CGI82
  • PSDR1
  • RALR1
  • SCALD
  • ARSDR1
  • HCBP12
  • RDJCSS
  • SDR7C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
disease perturbation
0.95
kinase perturbation
0.81
microRNA
0.74
cellular component
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.51   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.51   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (49)
1 – 10 of 49
TSPAN5
Tbio
Novelty:  0.08879443
p_int:  0.991463482
p_ni:  0.008536518
Score:  0.179
Data Source:  BioPlex,STRINGDB
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.894907442
p_ni:  0.105092558
Score:  0.231
Data Source:  BioPlex,STRINGDB
UBAC1
Tbio
Novelty:  0.00122518
p_int:  0.826360442
p_ni:  0.152855377
p_wrong:  0.020784182
Data Source:  BioPlex
PMEL
Tbio
Novelty:  0.00116525
p_int:  0.781586478
p_ni:  0.218413518
p_wrong:  4e-9
Score:  0.235
Data Source:  BioPlex,STRINGDB
RLBP1
Tbio
Novelty:  0.00526176
Score:  0.975
Data Source:  Reactome,STRINGDB
RBP1
Tbio
Novelty:  0.00199929
Score:  0.974
Data Source:  STRINGDB
LRAT
Tbio
Family:  Enzyme
Novelty:  0.00593203
Score:  0.966
Data Source:  STRINGDB
ALDH1A2
Tchem
Family:  Enzyme
Novelty:  0.00461371
Score:  0.962
Data Source:  STRINGDB
RPE65
Tbio
Family:  Enzyme
Novelty:  0.00147985
Score:  0.953
Data Source:  STRINGDB
ALDH1A1
Tchem
Family:  Enzyme
Novelty:  0.0012292
Score:  0.95
Data Source:  STRINGDB
Pathways (15)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Metabolism
Reactome
Metabolism of fat-soluble vitamins
Reactome
Metabolism of vitamins and cofactors
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Metabolism
Metabolism of fat-soluble vitamins
Metabolism of vitamins and cofactors
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
1
1
1
35
glomerular filtration rate
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
1
35
glomerular filtration rate
1
35
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
452986
Macaque
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
711195
Mouse
MGI:102581
17252
Rat
RGD:1312001
362757
Dog
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
480366
Species
Name
OMA
EggNOG
Inparanoid
Chimp
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
Macaque
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
Mouse
Rat
Dog
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
Publication Statistics
PubMed Score 40.51
PubMed score by year
PubTator Score 22.35
PubTator score by year