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Tbio
TBC1D15
TBC1 domain family member 15

Protein Summary
Description
Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity). This gene encodes a member of the Ras-like proteins in brain-GTPase activating protein superfamily that share a conserved Tre-2/Bub2/Cdc16 domain. The encoded protein interacts with Ras-like protein in brain 5A and may function as a regulator of intracellular trafficking. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319106
  • ENSP00000318262
  • ENSG00000121749
  • ENST00000485960
  • ENSP00000420678
  • ENST00000550746
  • ENSP00000448182

Symbol
  • RAB7-GAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.91
histone modification site profile
0.8
interacting protein
0.76
kinase perturbation
0.76
microRNA
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.24   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.24   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
GRAMD4
Tbio
Novelty:  0.12785672
p_int:  1
Score:  0.319
Data Source:  BioPlex,STRINGDB
KIF22
Tbio
Novelty:  0.0109594
p_int:  0.999999995
p_ni:  5e-9
Score:  0.254
Data Source:  BioPlex,STRINGDB
TBC1D17
Tdark
Novelty:  0.64376132
p_int:  0.999999985
p_ni:  1.2e-8
p_wrong:  3e-9
Score:  0.964
Data Source:  BioPlex,STRINGDB
CAMLG
Tbio
Novelty:  0.0088918
p_int:  0.999992491
p_ni:  0.000007509
Score:  0.188
Data Source:  BioPlex,STRINGDB
FIS1
Tbio
Novelty:  0.0033607
p_int:  0.998800784
p_ni:  0.001199216
Score:  0.971
Data Source:  BioPlex,STRINGDB
ATF6B
Tbio
Family:  TF
Novelty:  0.07061573
p_int:  0.996889312
p_ni:  0.003110688
Data Source:  BioPlex
STX12
Tbio
Novelty:  0.03836262
p_int:  0.993357765
p_ni:  0.006642235
Score:  0.294
Data Source:  BioPlex,STRINGDB
MRS2
Tbio
Novelty:  0.00264753
p_int:  0.991373464
p_ni:  0.008626536
Data Source:  BioPlex
CCDC121
Tdark
Novelty:  1.80941324
p_int:  0.984746168
p_ni:  0.015253832
Score:  0.665
Data Source:  BioPlex,STRINGDB
DNM1
Tbio
Novelty:  0.00319082
p_int:  0.978167947
p_ni:  0.021832053
Score:  0.344
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Rab regulation of trafficking
Reactome
TBC/RABGAPs
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Rab regulation of trafficking
TBC/RABGAPs
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
1
4
63.7
apolipoprotein B measurement
2
1
2
55.2
total cholesterol measurement
1
1
1
54.4
body mass index
2
1
2
44.2
body height
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
63.7
apolipoprotein B measurement
2
55.2
total cholesterol measurement
1
54.4
body mass index
2
44.2
body height
1
17.8
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 15
VGNC:5612
452079
Macaque
TBC1 domain family member 15
718743
Mouse
MGI:1913937
66687
Rat
RGD:1307920
366896
Dog
TBC1 domain family member 15
VGNC:47134
474451
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 15
Macaque
TBC1 domain family member 15
Mouse
Rat
Dog
TBC1 domain family member 15
Publication Statistics
PubMed Score 10.24
PubMed score by year
PubTator Score 4.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title