Tbio MDM1 Nuclear protein MDM1

Protein Summary

Description

Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). This gene encodes a microtubule-binding nuclear protein that localizes to the centrioles of dividing cells and differentiating multiciliated cells and negatively regulates centriole duplication. The encoded protein is closely associated with the centriole barrel, and resides in the centriole lumen. Naturally-occurring mutations in the orthologous mouse gene are associated with age-related retinal degeneration. [provided by RefSeq, Feb 2019]

Uniprot Accession IDs

• Q8TC05
• B4DM65
• E7EPQ3
• O43406
• Q8WTV9
• Q9NR04

Gene Name

• MDM1

Ensembl ID

• ENST00000303145
• ENSP00000302537
• ENSG00000111554
• ENST00000393543
• ENSP00000377175
• ENST00000411698
• ENSP00000391006
• ENST00000430606
• ENSP00000408694

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
histone modification site profile	0.83
virus perturbation	0.83
transcription factor binding site profile	0.78
transcription factor	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.27   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 123   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.27   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0