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Tbio
TRMT10A
tRNA methyltransferase 10 homolog A

Protein Summary
Description
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678, PubMed:25053765). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678). This gene encodes a protein that belongs to the tRNA (Guanine-1)-methyltransferase family. A similar gene in yeast modifies several different tRNA species. Mutations in this gene are associated with microcephaly, short stature, and impaired glucose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273962
  • ENSP00000273962
  • ENSG00000145331
  • ENST00000394876
  • ENSP00000378342
  • ENST00000394877
  • ENSP00000378343

Symbol
  • RG9MTD2
  • MSSGM
  • TRM10
  • MSSGM1
  • RG9MTD2
  • HEL-S-88
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
histone modification site profile
0.8
transcription factor
0.66
tissue sample
0.63
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.03   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.03   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
TRMT1
Tbio
Family:  Enzyme
Novelty:  0.01795504
Score:  0.906
Data Source:  STRINGDB
TRMT5
Tbio
Family:  Enzyme
Novelty:  0.02509765
Score:  0.904
Data Source:  STRINGDB
WDR4
Tbio
Family:  Enzyme
Novelty:  0.06887397
Score:  0.888
Data Source:  STRINGDB
METTL1
Tbio
Family:  Enzyme
Novelty:  0.03641249
Score:  0.856
Data Source:  STRINGDB
NSUN2
Tbio
Family:  Enzyme
Novelty:  0.01546947
Score:  0.85
Data Source:  STRINGDB
TRMT6
Tbio
Family:  Enzyme
Novelty:  0.06718902
Score:  0.803
Data Source:  STRINGDB
TRIT1
Tbio
Family:  Enzyme
Novelty:  0.00296723
Score:  0.801
Data Source:  STRINGDB
TRMT12
Tbio
Family:  Enzyme
Novelty:  0.12417204
Score:  0.8
Data Source:  STRINGDB
ADAT3
Tdark
Family:  Enzyme
Novelty:  0.04782001
Score:  0.798
Data Source:  STRINGDB
PUS1
Tbio
Family:  Enzyme
Novelty:  0.01923618
Score:  0.796
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
2
3
3
90.8
serum alanine aminotransferase measurement
2
2
1
5.6
67.5
viral load
1
1
1
66.8
triglyceride measurement
1
1
1
63.1
low density lipoprotein cholesterol measurement
1
1
1
63.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
90.8
serum alanine aminotransferase measurement
1
5.6
67.5
viral load
1
66.8
triglyceride measurement
1
63.1
low density lipoprotein cholesterol measurement
1
63.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 10A
VGNC:717
744323
Mouse
MGI:1920421
108943
Rat
RGD:1594565
295496
Dog
tRNA methyltransferase 10A
VGNC:47851
487872
Horse
tRNA methyltransferase 10A
VGNC:24533
100066636
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 10A
Mouse
Rat
Dog
tRNA methyltransferase 10A
Horse
tRNA methyltransferase 10A
Publication Statistics
PubMed Score 26.03
PubMed score by year
PubTator Score 8.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title