Tbio TRMT10A tRNA methyltransferase 10 homolog A

Protein Summary

Description

S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678, PubMed:25053765). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678). This gene encodes a protein that belongs to the tRNA (Guanine-1)-methyltransferase family. A similar gene in yeast modifies several different tRNA species. Mutations in this gene are associated with microcephaly, short stature, and impaired glucose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• Q8TBZ6
• B2R8X7
• Q9Y2T9

Gene Name

• TRMT10A

Ensembl ID

• ENST00000273962
• ENSP00000273962
• ENSG00000145331
• ENST00000394876
• ENSP00000378342
• ENST00000394877
• ENSP00000378343

Symbol

• RG9MTD2
• MSSGM
• TRM10
• MSSGM1
• RG9MTD2
• HEL-S-88

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.89
histone modification site profile	0.8
transcription factor	0.66
tissue sample	0.63
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.59   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 84   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.59   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0