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Tbio
WDR20
WD repeat-containing protein 20

Protein Summary
Description
Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336). This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299135
  • ENSP00000299135
  • ENSG00000140153
  • ENST00000322340
  • ENSP00000314209
  • ENST00000335263
  • ENSP00000335434
  • ENST00000342702
  • ENSP00000341037
  • ENST00000454394
  • ENSP00000406084
  • ENST00000555879
  • ENSP00000452470
  • ENST00000556511
  • ENSP00000451633
  • ENST00000556807
  • ENSP00000450636

Symbol
  • DMR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
histone modification site profile
0.84
microRNA
0.81
transcription factor perturbation
0.8
transcription factor binding site profile
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.14   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.14   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
53.8
reticulocyte count
2
1
2
21
platelet crit
1
1
1
17.5
reticulocyte measurement
2
1
2
17.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
53.8
reticulocyte count
2
21
platelet crit
1
17.5
reticulocyte measurement
2
17.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 20
VGNC:3288
453174
Macaque
WD repeat domain 20
708533
Mouse
MGI:1916891
69641
Rat
RGD:1306499
314453
Dog
WD repeat domain 20
VGNC:49741
611234
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 20
Macaque
WD repeat domain 20
Mouse
Rat
Dog
WD repeat domain 20
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8TBZ3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (31)
1 – 10 of 31
USP46
Tbio
Family: Enzyme
Novelty: 0.04594593
p_int: 1
Score: 0.943
Data Source: BioPlex,STRINGDB
FERMT2
Tbio
Novelty: 0.01020276
p_int: 0.999999919
p_ni: 8.1e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
TSPYL6
Tdark
Novelty: 0.68478376
p_int: 0.999879023
p_ni: 0.000120977
p_wrong: 1e-9
Score: 0.213
Data Source: BioPlex,STRINGDB
VSX2
Tbio
Family: TF
Novelty: 0.0046733
p_int: 0.999805535
p_ni: 0.000194464
p_wrong: 1e-9
Score: 0.2
Data Source: BioPlex,STRINGDB
FBXW5
Tbio
Novelty: 0.13100873
p_int: 0.99974693
p_ni: 0.000253008
p_wrong: 6.2e-8
Score: 0.163
Data Source: BioPlex,STRINGDB
OPTN
Tbio
Novelty: 0.00080427
p_int: 0.999522103
p_ni: 0.000143918
p_wrong: 0.000333979
Score: 0.189
Data Source: BioPlex,STRINGDB
RNF19B
Tbio
Family: Enzyme
Novelty: 0.20054824
p_int: 0.995576193
p_ni: 0.004423807
Score: 0.245
Data Source: BioPlex,STRINGDB
WDR48
Tbio
Novelty: 0.04070481
p_int: 0.987235257
p_ni: 0.012764743
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
TRIM35
Tbio
Novelty: 0.03280419
p_int: 0.983884516
p_ni: 0.016115484
Score: 0.159
Data Source: BioPlex,STRINGDB
MRM1
Tbio
Family: Enzyme
Novelty: 0.08762499
p_int: 0.966861085
p_ni: 0.033138915
Score: 0.15
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  65.14

PubMed score by year
PubTator Score  18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer