Tbio WDR66 Cilia- and flagella-associated protein 251

Protein Summary

Description

May regulate cilium motility through its role in the assembly of the axonemal radial spokes. This protein encoded by this gene belongs to the WD repeat-containing family of proteins, which function in the formation of protein-protein complexes in a variety of biological pathways. This family member appears to function in the determination of mean platelet volume (MPV), and polymorphisms in this gene have been associated with variance in MPV. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q8TBY9
• C9J1W2
• Q8IYA3
• Q8N898
• Q8NDE7
• CFAP251

Gene Name

• WDR66

Ensembl ID

• ENST00000288912
• ENSP00000288912
• ENSG00000158023
• ENST00000397454
• ENSP00000380595

Symbol

• CFAP251
• SPGF33
• CFAP251
• CaM-IP4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
tissue sample	0.66
histone modification site profile	0.61
trait	0.61
tissue	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.1   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 93   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.1   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0